Prp24: Difference between revisions

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'''Prp24''' ('''Pr'''e-mRNA splicing '''P'''rotein 24) is a [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae ''Saccharomyces cerevisiae''] yeast protein that functions in the formation of base pair interactions between the [http://en.wikipedia.org/wiki/U6_spliceosomal_RNA U6] and [http://en.wikipedia.org/wiki/U4_spliceosomal_RNA U4] [http://en.wikipedia.org/wiki/SnRNP snRNPs (small nuclear ribonucleoproteins] to form the U4/U6 di-snRNP in the assembly of the [http://en.wikipedia.org/wiki/Spliceosome spliceosome]. This protein is an octamer containing four RNA recognition motifs (RRMs) that function in the binding of Prp24 to U6 snRNA. These RRMs domains are conserved in structure and sequence in proteins orthologous to Prp24 in ''Homo sapiens'' and ''Schizosaccharomyces pombe'', as well as in other proteins containing RRMs.

== Introduction ==

===Prp24===

~~== Introduction ==~~

'''Prp24''' ('''Pr'''e-mRNA splicing '''P'''rotein 24) is a [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae ''Saccharomyces cerevisiae''] yeast protein that functions in the formation of base pair interactions between the [http://en.wikipedia.org/wiki/U6_spliceosomal_RNA U6] and [http://en.wikipedia.org/wiki/U4_spliceosomal_RNA U4] [http://en.wikipedia.org/wiki/SnRNP snRNPs (small nuclear ribonucleoproteins] to form the U4/U6 di-snRNP in the assembly of the [http://en.wikipedia.org/wiki/Spliceosome spliceosome]. This protein is an octamer containing four RNA recognition motifs (RRMs) that function in the binding of Prp24 to U6 snRNA. These RRMs domains are conserved in structure and sequence in proteins orthologous to Prp24 in ''Homo sapiens'' and ''Schizosaccharomyces pombe'', as well as in other proteins containing RRMs.

~~Prp24 is a nuclear protein associated with the U6 snRNP and functions in the base pair annealing of U6 snRNA to U4 snRNA of the U4 snRNP to form the U4/U6 di-snRNP~~

=== Pre-mRNA Splicing ===

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 {{STRUCTURE_2ghp|  PDB=2ghp  |  SCENE=  }}
-'''Prp24''' ('''Pr'''e-mRNA splicing '''P'''rotein 24) is a [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae ''Saccharomyces cerevisiae''] yeast protein that functions in the formation of base pair interactions between the [http://en.wikipedia.org/wiki/U6_spliceosomal_RNA U6] and [http://en.wikipedia.org/wiki/U4_spliceosomal_RNA U4] [http://en.wikipedia.org/wiki/SnRNP snRNPs (small nuclear ribonucleoproteins] to form the U4/U6 di-snRNP in the assembly of the [http://en.wikipedia.org/wiki/Spliceosome spliceosome].  This protein is an octamer containing four RNA recognition motifs (RRMs) that function in the binding of Prp24 to U6 snRNA.  These RRMs domains are conserved in structure and sequence in proteins orthologous to Prp24 in ''Homo sapiens'' and ''Schizosaccharomyces pombe'', as well as in other proteins containing RRMs.
+== Introduction ==
+===Prp24===
-== Introduction ==
+'''Prp24''' ('''Pr'''e-mRNA splicing '''P'''rotein 24) is a [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae ''Saccharomyces cerevisiae''] yeast protein that functions in the formation of base pair interactions between the [http://en.wikipedia.org/wiki/U6_spliceosomal_RNA U6] and [http://en.wikipedia.org/wiki/U4_spliceosomal_RNA U4] [http://en.wikipedia.org/wiki/SnRNP snRNPs (small nuclear ribonucleoproteins] to form the U4/U6 di-snRNP in the assembly of the [http://en.wikipedia.org/wiki/Spliceosome spliceosome].  This protein is an octamer containing four RNA recognition motifs (RRMs) that function in the binding of Prp24 to U6 snRNA.  These RRMs domains are conserved in structure and sequence in proteins orthologous to Prp24 in ''Homo sapiens'' and ''Schizosaccharomyces pombe'', as well as in other proteins containing RRMs.
-Prp24 is a nuclear protein associated with the U6 snRNP and functions in the base pair annealing of U6 snRNA to U4 snRNA of the U4 snRNP to form the U4/U6 di-snRNP
 === Pre-mRNA Splicing ===