Sandbox Reserved 347

This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada.

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Introduction

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D load='2iko' size='350' frame='false' scene=
2iko, resolution 1.90Å (default scene)
Ligands:	7IG
Gene:	REN (Homo sapiens)
Activity:	Renin, with EC number 3.4.23.15
Structural annotation: Resources: InterPro : Ipr009007, Ipr001461, Ipr012848, Ipr001969 Pfam : PF00026 UniProt : P00797
Functional annotation: Cellular component: extracellular space membrane Biological process: regulation of MAPKKK cascade regulation of blood pressure proteolysis angiotensin maturation Molecular function: hydrolase activity peptidase activity pepsin A activity renin activity receptor binding aspartic-type endopeptidase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Renin (pronounced /ˈriːnɨn/ REE-nin), also known as angiotensinogenase is an enzyme that participates in the body's renin-angiotensin system (RAS) that mediates extracellular volume (i.e., that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction.

Thus, it regulates the body's mean arterial blood pressure.

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Biochemistry

Renin is an aspartyl protease.

Function

Renin plays a key role in the Renin-Angiotension sysmtem (RAS). This system is responsible for the control of blood pressure and salt balances in mammals.

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