Sandbox Reserved 315: Difference between revisions
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{{Template:Sandbox_Reserved_BCMB307}} | {{Template:Sandbox_Reserved_BCMB307}} | ||
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=Introduction= | =Introduction= | ||
'''Orotidine monophosphate decarboxylase''' (ODCase), also known as '''orotidine 5’-monophosphate decarboxylase''' (OMP decarboxylase) or '''orotidine 5’-phosphate decarboxylase''' is an enzyme involved in pyrimidine biosynthesis. It catalyzes the conversion of orotidine 5’-monophosphate (OMP) to uridine 5’-monophosphate (UMP). This reaction is the final step in de novo pyrimidine nucleotide synthesis and is an essential precursor for both DNA and RNA. The main structure of orotidine monophosphate decarboxylase is a TIM barrel, with one side acting as the binding site, while the other side is closed-off. This enzyme has been studied for it’s extreme catalytic proficiency<Ref name = "Miller">PMID:10681417</ref>. | |||
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<scene name='Sandbox_Reserved_315/Practice_representation/1'>Representation</scene> | <scene name='Sandbox_Reserved_315/Practice_representation/1'>Representation</scene> | ||
= | =Catalytic Reaction= | ||
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[http://www.wikipedia.org Wikipedia] | [http://www.wikipedia.org Wikipedia] | ||
<Structure load=1dv7 size='200' frame='true' align='left' caption='Insert caption here' scene='Sandbox_Reserved_315/Practice_representation/1'/> | <Structure load=1dv7 size='200' frame='true' align='left' caption='Insert caption here' scene='Sandbox_Reserved_315/Practice_representation/1'/> | ||
=== | =Protein Structure= | ||
= | ==TIM Barrel== | ||
==Active Site== | |||
=Rate of Catalysis= | |||
==Substrate Destabilization== | |||
<Ref name = "Lee">PMID:9139656</ref> | |||
=References= | =References= | ||
<references/> | <references/> | ||
