2dz7: Difference between revisions

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==Overview==

The crystal structure of the tetragonal form of d(gcGAAAgc) has been, revised and reasonably refined including the disordered residues. The two, DNA strands form a base-intercalated duplex, and the four duplexes are, assembled according to the crystallographic 222 symmetry to form an, octaplex. In the central region, the eight strands are associated by, I-motif of double A-quartets. Furthermore, eight hydrated-magnesium, cations link the four duplexes to support the octaplex formation. Based on, these structural features, a proposal that folding of d(GAAA)n, found in, the non-coding region of genomes, into an octaplex can induce slippage, during replication to facilitate length polymorphism is presented.

The crystal structure of the tetragonal form of d(gcGAAAgc) has been revised and reasonably refined including the disordered residues. The two DNA strands form a base-intercalated duplex, and the four duplexes are assembled according to the crystallographic 222 symmetry to form an octaplex. In the central region, the eight strands are associated by I-motif of double A-quartets. Furthermore, eight hydrated-magnesium cations link the four duplexes to support the octaplex formation. Based on these structural features, a proposal that folding of d(GAAA)n, found in the non-coding region of genomes, into an octaplex can induce slippage during replication to facilitate length polymorphism is presented.

==About this Structure==

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==Reference==

DNA octaplex formation with an I-motif of water-mediated A-quartets: reinterpretation of the crystal structure of d(GCGAAAGC)., Sato Y, Mitomi K, Sunami T, Kondo J, Takenaka A, J Biochem ~~(Tokyo)~~. 2006 Dec;140(6):759-62. Epub 2006 Oct 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17062599 17062599]

DNA octaplex formation with an I-motif of water-mediated A-quartets: reinterpretation of the crystal structure of d(GCGAAAGC)., Sato Y, Mitomi K, Sunami T, Kondo J, Takenaka A, J Biochem. 2006 Dec;140(6):759-62. Epub 2006 Oct 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17062599 17062599]

[[Category: Protein complex]]

[[Category: Kondo, J.]]

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[[Category: vntr]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-The crystal structure of the tetragonal form of d(gcGAAAgc) has been, revised and reasonably refined including the disordered residues. The two, DNA strands form a base-intercalated duplex, and the four duplexes are, assembled according to the crystallographic 222 symmetry to form an, octaplex. In the central region, the eight strands are associated by, I-motif of double A-quartets. Furthermore, eight hydrated-magnesium, cations link the four duplexes to support the octaplex formation. Based on, these structural features, a proposal that folding of d(GAAA)n, found in, the non-coding region of genomes, into an octaplex can induce slippage, during replication to facilitate length polymorphism is presented.
+The crystal structure of the tetragonal form of d(gcGAAAgc) has been revised and reasonably refined including the disordered residues. The two DNA strands form a base-intercalated duplex, and the four duplexes are assembled according to the crystallographic 222 symmetry to form an octaplex. In the central region, the eight strands are associated by I-motif of double A-quartets. Furthermore, eight hydrated-magnesium cations link the four duplexes to support the octaplex formation. Based on these structural features, a proposal that folding of d(GAAA)n, found in the non-coding region of genomes, into an octaplex can induce slippage during replication to facilitate length polymorphism is presented.
 ==About this Structure==
@@ Line 10: / Line 10: @@
 ==Reference==
-DNA octaplex formation with an I-motif of water-mediated A-quartets: reinterpretation of the crystal structure of d(GCGAAAGC)., Sato Y, Mitomi K, Sunami T, Kondo J, Takenaka A, J Biochem (Tokyo). 2006 Dec;140(6):759-62. Epub 2006 Oct 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17062599 17062599]
+DNA octaplex formation with an I-motif of water-mediated A-quartets: reinterpretation of the crystal structure of d(GCGAAAGC)., Sato Y, Mitomi K, Sunami T, Kondo J, Takenaka A, J Biochem. 2006 Dec;140(6):759-62. Epub 2006 Oct 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17062599 17062599]
 [[Category: Protein complex]]
 [[Category: Kondo, J.]]
@@ Line 23: / Line 23: @@
 [[Category: vntr]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:09:35 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:04:25 2008''