Sandbox 55

Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013. spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Atorvastatin Atorvastatin, commercially known as Lipitor is a 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA Reductase) inhibitor. It is part of a class of medications known as statins that are cholesterol-lowering medications. HMG-CoA reductase catalyzes the committed step in cholesterol synthesis, so by inhibiting this step, low density lipoprotein (LDL) cholesterol can be effectively lowered. By lowering LDL, the likelihood of stroke and heart attack can be decreased. Considerations When Taking Atorvastatin Atorvastatin should be taken only in conjuction with a complete cholesterol-lowering program which includes diet, exercise, and weight control. Side Effects There are numerous side effects that can occur from taking atorvastatin. The most serious side effect although the most rare is myopathy (muscular weakness) with increased levels of creatinine kinase and rhabdomyolysis (rapid breakdown of skeletal muscle). Other more common side effects include headache, weakness, insomnia, peripheral edema, urinary tract infections, and flu-like symptoms. Atorvastatin has also been shown to elevate the levels of alanine transaminase (ALT) and aspartate transaminase (AST). Adverse Drug Interactions Atorvastatin can interact with many other drugs including, digoxin (E.g. digitalis), erythromycin, fenofibrate (E.g. Tricor), niacin, certain antifungal medications (E.g. Diflucan), certain cancer medications and steroids, and HIV/AIDS medications. spinqualitylabelsall models HMG-CoA Reductase in complex with Lipitor Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D References