Sandbox 55: Difference between revisions

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There are numerous side effects that can occur from taking atorvastatin. The most serious side effect although the most rare is myopathy (muscular weakness) with increased levels of creatinine kinase and rhabdomyolysis (rapid breakdown of skeletal muscle). Other more common side effects include headache, weakness, insomnia, peripheral edema, urinary tract infections, and flu-like symptoms<ref>"Lipitor (atorvastatin)." Medications and Drugs. HealthWise, 12 Aug. 2009. Web. 09 Mar. 2011. <http://www.emedicinehealth.com/drug-atorvastatin/article_em.htm>.</ref>. Atorvastatin has also been shown to elevate the levels of alanine transaminase (ALT) and aspartate transaminase (AST)<ref>Williams, D; Feely, J (2002). "Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors". Clin Pharmacokinet 41 (5): 343–70.</ref>.

~~===Adverse Drug Interactions===~~

Atorvastatin has been shown to cause fetal harm in pregnant women, so should never be prescribed in women who are pregnant. Cholesterol levels and triacylglycerols increase naturally during pregnancy and are essential for the development of the fetus, and slowing production of cholesterol could have detrimental effects on the fetus <ref>Lipitor: Prescribing Information. Pfizer. June 2009.</ref>.

Atorvastatin ~~can interact with many other drugs including~~, ~~digoxin (E~~.~~g. digitalis), erythromycin, fenofibrate (E.g. Tricor), niacin, certain antifungal medications (E.g. Diflucan), certain cancer medications~~ and ~~steroids~~, and ~~HIV/AIDS medications~~<ref>"Lipitor ~~(atorvastatin)~~.~~" Medications and Drugs. HealthWise, 12 Aug~~. 2009~~. Web. 09 Mar. 2011. <http://www.emedicinehealth.com/drug-atorvastatin/article_em.htm>~~.</ref>.

===Adverse Food and Drug Interactions===

Atorvastatin can interact with many other drugs including, digoxin (E.g. digitalis),warfarin, erythromycin, fenofibrate (E.g. Tricor), niacin, certain antifungal medications (E.g. Diflucan), certain cancer medications and steroids, and HIV/AIDS medications<ref>"Lipitor (atorvastatin)." Medications and Drugs. HealthWise, 12 Aug. 2009. Web. 09 Mar. 2011. <http://www.emedicinehealth.com/drug-atorvastatin/article_em.htm>.</ref>.

Vitamin D actually lowers atorvastatin active metabolite concentrations<ref>Schwartz, JB (February 2009). "Effects of vitamin D supplementation in atorvastatin-treated patients: a new drug interaction with an unexpected consequence". Clin Pharmacol Ther 85 (2): 198–203.</ref>. Interestingly, grapefruit juice in co-administration with atorvastatin increases atorvastatin's Cmax (rate of absorption) and AUC (extent of absorption) which can lead to adverse effects. Grapefruit juice is a known inhibitor of Cytochrome P450 3A4 (CYP3A4), which is involved in the deactivation of avtorvastatin for excretion from the body<ref>Kane, GC; Lipsky, JJ (September 2000). "Drug-grapefruit juice interactions". Mayo Clin Proc 75 (9): 933–42</ref>.

Sandbox 55: Difference between revisions

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 There are numerous side effects that can occur from taking atorvastatin. The most serious side effect although the most rare is myopathy (muscular weakness) with increased levels of creatinine kinase and rhabdomyolysis (rapid breakdown of skeletal muscle). Other more common side effects include headache, weakness, insomnia, peripheral edema, urinary tract infections, and flu-like symptoms<ref>"Lipitor (atorvastatin)." Medications and Drugs. HealthWise, 12 Aug. 2009. Web. 09 Mar. 2011. <http://www.emedicinehealth.com/drug-atorvastatin/article_em.htm>.</ref>. Atorvastatin has also been shown to elevate the levels of alanine transaminase (ALT) and aspartate transaminase (AST)<ref>Williams, D; Feely, J (2002). "Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors". Clin Pharmacokinet 41 (5): 343–70.</ref>.
-===Adverse Drug Interactions===
+Atorvastatin has been shown to cause fetal harm in pregnant women, so should never be prescribed in women who are pregnant. Cholesterol levels and triacylglycerols increase naturally during pregnancy and are essential for the development of the fetus, and slowing production of cholesterol could have detrimental effects on the fetus <ref>Lipitor: Prescribing Information. Pfizer. June 2009.</ref>.
-Atorvastatin can interact with many other drugs including, digoxin (E.g. digitalis), erythromycin, fenofibrate (E.g. Tricor), niacin, certain antifungal medications (E.g. Diflucan), certain cancer medications and steroids, and HIV/AIDS medications<ref>"Lipitor (atorvastatin)." Medications and Drugs. HealthWise, 12 Aug. 2009. Web. 09 Mar. 2011. <http://www.emedicinehealth.com/drug-atorvastatin/article_em.htm>.</ref>.
+===Adverse Food and Drug Interactions===
+Atorvastatin can interact with many other drugs including, digoxin (E.g. digitalis),warfarin, erythromycin, fenofibrate (E.g. Tricor), niacin, certain antifungal medications (E.g. Diflucan), certain cancer medications and steroids, and HIV/AIDS medications<ref>"Lipitor (atorvastatin)." Medications and Drugs. HealthWise, 12 Aug. 2009. Web. 09 Mar. 2011. <http://www.emedicinehealth.com/drug-atorvastatin/article_em.htm>.</ref>.
+Vitamin D actually lowers atorvastatin active metabolite concentrations<ref>Schwartz, JB (February 2009). "Effects of vitamin D supplementation in atorvastatin-treated patients: a new drug interaction with an unexpected consequence". Clin Pharmacol Ther 85 (2): 198–203.</ref>. Interestingly, grapefruit juice in co-administration with atorvastatin increases atorvastatin's Cmax (rate of absorption) and AUC (extent of absorption) which can lead to adverse effects. Grapefruit juice is a known inhibitor of Cytochrome P450 3A4 (CYP3A4), which is involved in the deactivation of avtorvastatin for excretion from the body<ref>Kane, GC; Lipsky, JJ (September 2000). "Drug-grapefruit juice interactions". Mayo Clin Proc 75 (9): 933–42</ref>.