Sandbox 55: Difference between revisions
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=Atorvastatin= | =Atorvastatin= | ||
Atorvastatin, commercially known as Lipitor is a 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA Reductase) inhibitor. It is part of a class of medications known as statins that are cholesterol-lowering medications<ref>Phizer Inc. "Lipitor." Lipitor: Atorvastatin Calcium Tablets. Phizer Inc., 2011. Web. 09 Mar. 2011. <http://www.lipitor.com/aboutLipitor.aspx>.</ref>. HMG-CoA reductase catalyzes the committed step in cholesterol synthesis, so by inhibiting this step, low density lipoprotein (LDL) cholesterol can be effectively lowered. By lowering LDL, the likelihood of stroke and heart attack can be decreased<ref>NIH. "Atorvastatin." PubMed Health. National Institutes of Health, 01 July 2010. Web. 09 Mar. 2011. <http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000009/>.</ref>. | Atorvastatin, commercially known as Lipitor is a 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA Reductase) inhibitor that works primarily in the liver<ref>LDL-C, Decreasing. "DrugBank: Atorvastatin (DB01076)." DrugBank: Welcome. Web. 09 Mar. 2011. <http://www.drugbank.ca/drugs/DB01076>.</ref>. It is part of a class of medications known as statins that are cholesterol-lowering medications<ref>Phizer Inc. "Lipitor." Lipitor: Atorvastatin Calcium Tablets. Phizer Inc., 2011. Web. 09 Mar. 2011. <http://www.lipitor.com/aboutLipitor.aspx>.</ref>. HMG-CoA reductase catalyzes the committed step in cholesterol synthesis, so by inhibiting this step, low density lipoprotein (LDL) cholesterol can be effectively lowered. By lowering LDL, the likelihood of stroke and heart attack can be decreased<ref>NIH. "Atorvastatin." PubMed Health. National Institutes of Health, 01 July 2010. Web. 09 Mar. 2011. <http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000009/>.</ref>. | ||
Bruce Roth, a Phizer employee, first synthesized atorvastatin in 1985. In 2008 Lipitor was the top-selling pharmaceutical in the world with $12.4 billion in sales. However, Lipitor's US patent protection is scheduled to expire in June 2011<ref>^"Pfizer wins patent extension on cholesterol drug". Associated Press. 6 January 2009. http://www.nj.com/business/index.ssf/2009/01/pfizer_wins_patent_extension_o.html.</ref>. | Bruce Roth, a Phizer employee, first synthesized atorvastatin in 1985. In 2008 Lipitor was the top-selling pharmaceutical in the world with $12.4 billion in sales. However, Lipitor's US patent protection is scheduled to expire in June 2011<ref>^"Pfizer wins patent extension on cholesterol drug". Associated Press. 6 January 2009. http://www.nj.com/business/index.ssf/2009/01/pfizer_wins_patent_extension_o.html.</ref>. | ||
==Structure== | |||
===Chemical Properties=== | |||
Formula: C<sub>33</sub>H<sub>35</sub>FN<sub>2</sub>O<sub>5</sub> | |||
Molecular Mass: 558.64 g/mol | |||
Half life: 14 hours | |||
Excretion: Bile | |||
==Considerations When Taking Atorvastatin== | ==Considerations When Taking Atorvastatin== | ||
Atorvastatin should be taken only in conjuction with a complete cholesterol-lowering program which includes diet, exercise, and weight control<ref>"Atorvastatin." Cerner Multum, Inc., 12 Aug. 2009. Web. 09 Mar. 2011. <http://www.drugs.com/atorvastatin.html>.</ref>. | Atorvastatin should be taken only in conjuction with a complete cholesterol-lowering program which includes diet, exercise, and weight control<ref>"Atorvastatin." Cerner Multum, Inc., 12 Aug. 2009. Web. 09 Mar. 2011. <http://www.drugs.com/atorvastatin.html>.</ref>. | ||
