Sandbox 55: Difference between revisions

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==HMG-CoA Reductase==
==HMG-CoA Reductase==


HMG-CoA is an endoplasmic reticulum transmembrane glycoprotein. It is a tetramer and an NADPH-dependent enzyme. HMG-CoA reductase contains an N-terminal membrane domain and a C-terminal catalytic domain. The catalytic portion can be further subdivided into an N-domain (N-terminal), a large L-domain, and a small S-domain. The L-domain binds the substrate, and the S-domain binds NADP<ref>"Pfam: Family: HMG-CoA_red (PF00368)." Pfam: Home Page. Web. 10 Mar. 2011. <http://pfam.sanger.ac.uk/family?acc=PF00368>.</ref>.  
===Structural Features===
HMG-CoA is an endoplasmic reticulum transmembrane glycoprotein. It is a tetramer and <scene name='Sandbox_55/Nadph/1'>NADPH-dependent</scene> (ligands with orange atoms) enzyme. HMG-CoA reductase contains an N-terminal membrane domain and a C-terminal catalytic domain. The catalytic portion can be further subdivided into an N-domain (N-terminal), a large L-domain, and a small S-domain. The L-domain binds the substrate, and the S-domain binds NADP<ref>"Pfam: Family: HMG-CoA_red (PF00368)." Pfam: Home Page. Web. 10 Mar. 2011. <http://pfam.sanger.ac.uk/family?acc=PF00368>.</ref>.  
 


===Mechanism of Action===
===Mechanism of Action===
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