Sandbox 55: Difference between revisions
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==HMG-CoA Reductase== | ==HMG-CoA Reductase== | ||
<applet load='1hwk' size='350' frame='true' align='left' caption='HMG-CoA Reductase in complex with Lipitor' /> | |||
===Structural Features=== | ===Structural Features=== | ||
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===Active Site=== | ===Active Site=== | ||
The <scene name='Sandbox_55/Four_active_sites_and_residues/1'>four active sites</scene> of HMG-CoA reductase are located at the interface of the two monomers of a dimer (represented by the ball and stick residues). Each active site has a loop that folds over part of the binding pocket; the loop contains an unusual cis-peptide bond that is highly conserved. The loop folds over the active site when both substrates (HMG-CoA and NADPH) are bound to exclude solvent from the active site. | The <scene name='Sandbox_55/Four_active_sites_and_residues/1'>four active sites</scene> of HMG-CoA reductase are located at the interface of the two monomers of a dimer (represented by the ball and stick residues). Each active site has a loop that folds over part of the binding pocket; the loop contains an unusual cis-peptide bond that is highly conserved. The loop folds over the active site when both substrates (HMG-CoA and NADPH) are bound to exclude solvent from the active site. | ||
