Sandbox 55: Difference between revisions
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Vitamin D actually lowers atorvastatin active metabolite concentrations<ref>Schwartz, JB (February 2009). "Effects of vitamin D supplementation in atorvastatin-treated patients: a new drug interaction with an unexpected consequence". Clin Pharmacol Ther 85 (2): 198–203.</ref>. Interestingly, grapefruit juice in co-administration with atorvastatin increases atorvastatin's Cmax (rate of absorption) and AUC (extent of absorption) which can lead to adverse effects. Grapefruit juice is a known inhibitor of Cytochrome P450 3A4 (CYP3A4), which is involved in the deactivation of avtorvastatin for excretion from the body<ref>Kane, GC; Lipsky, JJ (September 2000). "Drug-grapefruit juice interactions". Mayo Clin Proc 75 (9): 933–42</ref>. | Vitamin D actually lowers atorvastatin active metabolite concentrations<ref>Schwartz, JB (February 2009). "Effects of vitamin D supplementation in atorvastatin-treated patients: a new drug interaction with an unexpected consequence". Clin Pharmacol Ther 85 (2): 198–203.</ref>. Interestingly, grapefruit juice in co-administration with atorvastatin increases atorvastatin's Cmax (rate of absorption) and AUC (extent of absorption) which can lead to adverse effects. Grapefruit juice is a known inhibitor of Cytochrome P450 3A4 (CYP3A4), which is involved in the deactivation of avtorvastatin for excretion from the body<ref>Kane, GC; Lipsky, JJ (September 2000). "Drug-grapefruit juice interactions". Mayo Clin Proc 75 (9): 933–42</ref>. | ||
===Administration and Cost=== | |||
Atorvastatin is an oral medication available in 10, 20, and 40 mg sizes, with average prices being $1.82, $2.82, and $3.40 respectively. The starting does is usually 10 mg daily, and blood LDL levels should be checked four weeks after starting because the maximal effects of atorvastatin can be at that time. <ref>Goshman, Lorna. "Perspective on Cholesterol Lowering Agents: Atorvastatin." Journal of the Pharmacy Society of Wisconsin (1998): 28-34. Print.</ref> | |||
[[Image:Atorvastatin-lipitor.jpg|right|]] | |||
=Targets= | =Targets= | ||
