Alendronate: Difference between revisions
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== Structure and General Function == | == Structure and General Function == | ||
[[Image:Alendronate.gif]]<ref>Image from: http://pharmacy-and-drugs.com</ref> | [[Image:Alendronate.gif]]<ref>Image from: http://pharmacy-and-drugs.com</ref> | ||
Alendronate is an aminobisphosphonate with a nonhydrolyzable P-C-P. Alendronate generally affects the activity of osteoclasts in bone. Osteoclasts are responsible for breaking down bone and also for bone resorption (losing bone substance). <ref>http://www.medterms.com/script/main/art.asp?articlekey=11794</ref> When alendronate is present, bone resorption is inhibited and bone breakdown is diminished. | Alendronate is an aminobisphosphonate with a nonhydrolyzable P-C-P. Alendronate generally affects the activity of osteoclasts in bone. Osteoclasts are responsible for breaking down bone and also for bone resorption (losing bone substance). <ref>http://www.medterms.com/script/main/art.asp?articlekey=11794</ref> When alendronate is present, bone resorption is inhibited and bone breakdown is diminished. | ||
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The deactivation of FPPS causes a disruption of prenylation in the cell and thus affects various GTPases. For instance, it will incorrectly activate the GTPases Rho, Rac, and Cdc42.<ref>http://www.ncbi.nlm.nih.gov/pubmed/16734383</ref> The inhibition of post-translational prenylation of Ras is likely to cause cell apoptosis. <ref>http://www.ncbi.nlm.nih.gov/pubmed/9556058</ref> | The deactivation of FPPS causes a disruption of prenylation in the cell and thus affects various GTPases. For instance, it will incorrectly activate the GTPases Rho, Rac, and Cdc42.<ref>http://www.ncbi.nlm.nih.gov/pubmed/16734383</ref> The inhibition of post-translational prenylation of Ras is likely to cause cell apoptosis. <ref>http://www.ncbi.nlm.nih.gov/pubmed/9556058</ref> | ||
==== FPPS Substrate ==== | ==== FPPS Substrate ==== | ||
