Alendronate: Difference between revisions
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[[Alendronate]] (''Fosamax'') is commonly known for its use in treatment and prevention of osteoporosis in postmenopausal women and men, but is also used to treat Paget's disease (disease that results in deformed and enlarged bones).<ref>http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000018/</ref> Alendronate belongs to the class of nitrogen-containing bisphosphonates, which are inorganic pyrophosphate analogues. | |||
== History of Bisphosphonates == | == History of Bisphosphonates == | ||
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Isopentenyl pyrophosphate (IPP) actually binds to and stabilizes the alendronate-FPPS complex, rather than competing with the inhibitor.<ref>http://www.rcsb.org/pdb/explore/explore.do?structureId=2F92</ref> IPP can be seen in complex with FPPS and zoledronate | Isopentenyl pyrophosphate (IPP) actually binds to and stabilizes the alendronate-FPPS complex, rather than competing with the inhibitor.<ref>http://www.rcsb.org/pdb/explore/explore.do?structureId=2F92</ref> IPP can be seen in complex with FPPS and zoledronate | ||
<scene name='Sandbox_59/Ipp_and_zol/2'>here</scene>. (Zoledronate is also an aminobisphosphonate) | <scene name='Sandbox_59/Ipp_and_zol/2'>here</scene>. (Zoledronate is also an aminobisphosphonate) | ||
== References == | == References == | ||
<references/> | <references/> | ||
