Simvastatin Synthase: Difference between revisions

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==Simvastatin Synthase==
{{STRUCTURE_3hle |  PDB=3hle  |  SCENE=  }}
{{STRUCTURE_3hle |  PDB=3hle  |  SCENE=  }}
 
Simvastation synthase (LovD) is an enzyme isolatied from the natural product biosynthetic pathways of''Aspergillus terreus''.
Simvastatin Synthase, LovD, is an acyltransferase that converts the inactive monacolin J acid (MJA) into the cholesterol-lowering lovastatin. LovD can also synthesize the blockbuster drug simvastatin using MJA and a synthetic alpha-dimethylbutyryl thioester, albeit with suboptimal properties as a biocatalyst.
Simvastatin Synthase is an acyltransferase that converts the inactive monacolin J acid (MJA) into the cholesterol-lowering lovastatin. LovD can also synthesize the blockbuster drug simvastatin using MJA and a synthetic alpha-dimethylbutyryl thioester, albeit with suboptimal properties as a biocatalyst.
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