3l15: Difference between revisions

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[[Image:3l15.png|left|200px]]
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The line below this paragraph, containing "STRUCTURE_3l15", creates the "Structure Box" on the page.
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{{STRUCTURE_3l15|  PDB=3l15  |  SCENE=  }}  
{{STRUCTURE_3l15|  PDB=3l15  |  SCENE=  }}  
===Human Tead2 transcriptional factor===
===Human Tead2 transcriptional factor===
{{ABSTRACT_PUBMED_20368466}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/TEAD2_HUMAN TEAD2_HUMAN]] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.<ref>PMID:18579750</ref> <ref>PMID:19324877</ref>
The line below this paragraph, {{ABSTRACT_PUBMED_20368466}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_20368466}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:20368466</ref><ref group="xtra">PMID:18258486</ref><ref group="xtra">PMID:19324876</ref><ref group="xtra">PMID:18579750</ref><references group="xtra"/>
<ref group="xtra">PMID:020368466</ref><ref group="xtra">PMID:018258486</ref><ref group="xtra">PMID:019324876</ref><ref group="xtra">PMID:018579750</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Luo, X.]]
[[Category: Luo, X.]]
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