3jz9: Difference between revisions

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[[Image:3jz9.png|left|200px]]
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{{STRUCTURE_3jz9|  PDB=3jz9  |  SCENE=  }}  
{{STRUCTURE_3jz9|  PDB=3jz9  |  SCENE=  }}  
===Crystal structure of the GEF domain of DrrA/SidM from Legionella pneumophila===
===Crystal structure of the GEF domain of DrrA/SidM from Legionella pneumophila===
{{ABSTRACT_PUBMED_20064470}}


 
==Function==
<!--  
[[http://www.uniprot.org/uniprot/Q5ZSQ3_LEGPH Q5ZSQ3_LEGPH]] Virulence effector that plays a key role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a GDP-GTP exchange factor (GEF) for the small GTPase Rab1 (RAB1A, RAB1B or RAB1C), thereby converting Rab1 to an active GTP-bound state, leading to the incorporation of Rab1 into LCVs. Also shows RabGDI displacement factor (GDF) activity; however, this probably represents a passive activity following the GEF activity. Also acts as an adenylyltransferase by mediating the addition of adenosine 5'-monophosphate (AMP) to 'Tyr-77' of host RAB1B, thereby rendering RAB1B constitutively active. Also has adenylyltransferase activity towards Rab6 and Rab35. Also displays guanylyltransferase activity by mediating the addition of guanosine 5'-monophosphate (GMP) to host RAB1B in vitro; however such activity remains uncertain in vivo. Specifically binds phosphatidylinositol 4-phosphate (PtdIns(4)P) lipids on the cytosolic surface of the phagosomal membrane shortly after infection.<ref>PMID:16824952</ref><ref>PMID:17947549</ref><ref>PMID:21822290</ref><ref>PMID:20064470</ref><ref>PMID:19942850</ref><ref>PMID:20176951</ref>  
The line below this paragraph, {{ABSTRACT_PUBMED_20064470}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_20064470}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:20064470</ref><ref group="xtra">PMID:17947549</ref><ref group="xtra">PMID:17952054</ref><references group="xtra"/>
<ref group="xtra">PMID:020064470</ref><ref group="xtra">PMID:017947549</ref><ref group="xtra">PMID:017952054</ref><references group="xtra"/><references/>
[[Category: Legionella pneumophila subsp. pneumophila str. philadelphia 1]]
[[Category: Legionella pneumophila subsp. pneumophila str. philadelphia 1]]
[[Category: Blankenfeldt, W.]]
[[Category: Blankenfeldt, W.]]
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[[Category: Rabgdi]]
[[Category: Rabgdi]]
[[Category: Rabgef]]
[[Category: Rabgef]]
[[Category: Transport protein]]
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