2in6: Difference between revisions

Revision as of 13:05, 30 January 2013

2in6 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Smaill JB, Baker EN, Booth RJ, Bridges AJ, Dickson JM, Dobrusin EM, Ivanovic I, Kraker AJ, Lee HH, Lunney EA, Ortwine DF, Palmer BD, Quin J 3rd, Squire CJ, Thompson AM, Denny WA. Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases. Eur J Med Chem. 2008 Jun;43(6):1276-96. Epub 2007 Aug 6. PMID:17869387 doi:10.1016/j.ejmech.2007.07.016
Squire CJ, Dickson JM, Ivanovic I, Baker EN. Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation. Structure. 2005 Apr;13(4):541-50. PMID:15837193 doi:10.1016/j.str.2004.12.017

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 [[Image:2in6.png|left|200px]]
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 ===Wee1 kinase complex with inhibitor PD311839===
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 ==Reference==
-<ref group="xtra">PMID:17869387</ref><ref group="xtra">PMID:15837193</ref><references group="xtra"/>
+<ref group="xtra">PMID:017869387</ref><ref group="xtra">PMID:015837193</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
 [[Category: Non-specific protein-tyrosine kinase]]