2pzy: Difference between revisions
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==Overview== | ==Overview== | ||
The discovery of a series of potent, carboline-based MK2 inhibitors is | The discovery of a series of potent, carboline-based MK2 inhibitors is described. These compounds inhibit MK2 with IC50s as low as 10 nM, as measured in a DELFIA assay. An X-ray crystal structure reveals that they bind in a region near the p-loop and the hinge region of MK2a. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Emmanuel, M.]] | [[Category: Emmanuel, M.]] | ||
[[Category: Gautschi, E.]] | [[Category: Gautschi, E.]] | ||
[[Category: Goldberg, D | [[Category: Goldberg, D R.]] | ||
[[Category: Kashem, M | [[Category: Kashem, M A.]] | ||
[[Category: Lukas, S.]] | [[Category: Lukas, S.]] | ||
[[Category: Mao, W.]] | [[Category: Mao, W.]] | ||
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[[Category: Moss, N.]] | [[Category: Moss, N.]] | ||
[[Category: Pargellis, C.]] | [[Category: Pargellis, C.]] | ||
[[Category: Patel, U | [[Category: Patel, U R.]] | ||
[[Category: Patnaude, L.]] | [[Category: Patnaude, L.]] | ||
[[Category: Peet, G | [[Category: Peet, G W.]] | ||
[[Category: Skow, D.]] | [[Category: Skow, D.]] | ||
[[Category: Snow, R | [[Category: Snow, R J.]] | ||
[[Category: Wang, J.]] | [[Category: Wang, J.]] | ||
[[Category: Ward, Y.]] | [[Category: Ward, Y.]] | ||
[[Category: Werneburg, B.]] | [[Category: Werneburg, B.]] | ||
[[Category: White, A.]] | [[Category: White, A.]] | ||
[[Category: Wu, J | [[Category: Wu, J P.]] | ||
[[Category: B18]] | [[Category: B18]] | ||
[[Category: STU]] | [[Category: STU]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:34:40 2008'' | ||
