2pm6: Difference between revisions

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==Overview==

COPII-coated vesicles export newly synthesized proteins from the, endoplasmic reticulum. The COPII coat consists of the Sec23/24-Sar1, complex that selects cargo and the Sec13/31 assembly unit that can, polymerize into an octahedral cage and deform the membrane into a bud., Crystallographic analysis of the assembly unit reveals a 28 nm long rod, comprising a central alpha-solenoid dimer capped by two beta-propeller, domains at each end. We construct a molecular model of the COPII cage by, fitting Sec13/31 crystal structures into a recently determined electron, microscopy density map. The vertex geometry involves four copies of the, Sec31 beta-propeller that converge through their axial ends; there is no, interdigitation of assembly units of the kind seen in clathrin cages. We, also propose that the assembly unit has a central hinge-an arrangement of, interlocked alpha-solenoids-about which it can bend to adapt to cages of, variable curvature.

COPII-coated vesicles export newly synthesized proteins from the endoplasmic reticulum. The COPII coat consists of the Sec23/24-Sar1 complex that selects cargo and the Sec13/31 assembly unit that can polymerize into an octahedral cage and deform the membrane into a bud. Crystallographic analysis of the assembly unit reveals a 28 nm long rod comprising a central alpha-solenoid dimer capped by two beta-propeller domains at each end. We construct a molecular model of the COPII cage by fitting Sec13/31 crystal structures into a recently determined electron microscopy density map. The vertex geometry involves four copies of the Sec31 beta-propeller that converge through their axial ends; there is no interdigitation of assembly units of the kind seen in clathrin cages. We also propose that the assembly unit has a central hinge-an arrangement of interlocked alpha-solenoids-about which it can bend to adapt to cages of variable curvature.

==About this Structure==

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[[Category: Fath, S.]]

[[Category: Goldberg, J.]]

[[Category: Mancias, J.D.]]

[[Category: Mancias, J D.]]

[[Category: alpha solenoid]]

[[Category: beta propeller]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jan 23 14~~:29:35 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:30:57 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-COPII-coated vesicles export newly synthesized proteins from the, endoplasmic reticulum. The COPII coat consists of the Sec23/24-Sar1, complex that selects cargo and the Sec13/31 assembly unit that can, polymerize into an octahedral cage and deform the membrane into a bud., Crystallographic analysis of the assembly unit reveals a 28 nm long rod, comprising a central alpha-solenoid dimer capped by two beta-propeller, domains at each end. We construct a molecular model of the COPII cage by, fitting Sec13/31 crystal structures into a recently determined electron, microscopy density map. The vertex geometry involves four copies of the, Sec31 beta-propeller that converge through their axial ends; there is no, interdigitation of assembly units of the kind seen in clathrin cages. We, also propose that the assembly unit has a central hinge-an arrangement of, interlocked alpha-solenoids-about which it can bend to adapt to cages of, variable curvature.
+COPII-coated vesicles export newly synthesized proteins from the endoplasmic reticulum. The COPII coat consists of the Sec23/24-Sar1 complex that selects cargo and the Sec13/31 assembly unit that can polymerize into an octahedral cage and deform the membrane into a bud. Crystallographic analysis of the assembly unit reveals a 28 nm long rod comprising a central alpha-solenoid dimer capped by two beta-propeller domains at each end. We construct a molecular model of the COPII cage by fitting Sec13/31 crystal structures into a recently determined electron microscopy density map. The vertex geometry involves four copies of the Sec31 beta-propeller that converge through their axial ends; there is no interdigitation of assembly units of the kind seen in clathrin cages. We also propose that the assembly unit has a central hinge-an arrangement of interlocked alpha-solenoids-about which it can bend to adapt to cages of variable curvature.
 ==About this Structure==
@@ Line 16: / Line 16: @@
 [[Category: Fath, S.]]
 [[Category: Goldberg, J.]]
-[[Category: Mancias, J.D.]]
+[[Category: Mancias, J D.]]
 [[Category: alpha solenoid]]
 [[Category: beta propeller]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:29:35 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:30:57 2008''