2pp4: Difference between revisions

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==Overview==

The eight twenty-one protein, ETO, is implicated in 12%-15% of acute human, leukemias as part of a gene fusion with RUNX1 (also called AML1). Of the, four ETO domains related to Drosophila melanogaster Nervy, only two are, required to induce spontaneous myeloid leukemia upon transplantation into, the mouse. One of these domains is related in sequence to TAF4, a, component of TFIID. The structure of this domain, ETO-TAFH, is similar to, yeast Rpb4 and to Escherichia coli sigma(70); it is the first TAF-related, protein with structural similarity to the multisubunit RNA polymerases., Overlapping surfaces of ETO-TAFH interact with an autonomous repression, domain of the nuclear receptor corepressor N-CoR and with a conserved, activation domain from the E-box family of transcription factors. Thus, ETO-TAFH acts as a structural platform that can interchange negative and, positive coregulatory proteins to control transcription.

The eight twenty-one protein, ETO, is implicated in 12%-15% of acute human leukemias as part of a gene fusion with RUNX1 (also called AML1). Of the four ETO domains related to Drosophila melanogaster Nervy, only two are required to induce spontaneous myeloid leukemia upon transplantation into the mouse. One of these domains is related in sequence to TAF4, a component of TFIID. The structure of this domain, ETO-TAFH, is similar to yeast Rpb4 and to Escherichia coli sigma(70); it is the first TAF-related protein with structural similarity to the multisubunit RNA polymerases. Overlapping surfaces of ETO-TAFH interact with an autonomous repression domain of the nuclear receptor corepressor N-CoR and with a conserved activation domain from the E-box family of transcription factors. Thus, ETO-TAFH acts as a structural platform that can interchange negative and positive coregulatory proteins to control transcription.

==About this Structure==

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[[Category: Liu, S.]]

[[Category: Wei, Y.]]

[[Category: Werner, M.H.]]

[[Category: Werner, M H.]]

[[Category: Woodrell, C.]]

[[Category: Yokoyama, S.]]

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[[Category: transcriptional cofactor]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:31:46 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-The eight twenty-one protein, ETO, is implicated in 12%-15% of acute human, leukemias as part of a gene fusion with RUNX1 (also called AML1). Of the, four ETO domains related to Drosophila melanogaster Nervy, only two are, required to induce spontaneous myeloid leukemia upon transplantation into, the mouse. One of these domains is related in sequence to TAF4, a, component of TFIID. The structure of this domain, ETO-TAFH, is similar to, yeast Rpb4 and to Escherichia coli sigma(70); it is the first TAF-related, protein with structural similarity to the multisubunit RNA polymerases., Overlapping surfaces of ETO-TAFH interact with an autonomous repression, domain of the nuclear receptor corepressor N-CoR and with a conserved, activation domain from the E-box family of transcription factors. Thus, ETO-TAFH acts as a structural platform that can interchange negative and, positive coregulatory proteins to control transcription.
+The eight twenty-one protein, ETO, is implicated in 12%-15% of acute human leukemias as part of a gene fusion with RUNX1 (also called AML1). Of the four ETO domains related to Drosophila melanogaster Nervy, only two are required to induce spontaneous myeloid leukemia upon transplantation into the mouse. One of these domains is related in sequence to TAF4, a component of TFIID. The structure of this domain, ETO-TAFH, is similar to yeast Rpb4 and to Escherichia coli sigma(70); it is the first TAF-related protein with structural similarity to the multisubunit RNA polymerases. Overlapping surfaces of ETO-TAFH interact with an autonomous repression domain of the nuclear receptor corepressor N-CoR and with a conserved activation domain from the E-box family of transcription factors. Thus, ETO-TAFH acts as a structural platform that can interchange negative and positive coregulatory proteins to control transcription.
 ==About this Structure==
@@ Line 19: / Line 19: @@
 [[Category: Liu, S.]]
 [[Category: Wei, Y.]]
-[[Category: Werner, M.H.]]
+[[Category: Werner, M H.]]
 [[Category: Woodrell, C.]]
 [[Category: Yokoyama, S.]]
@@ Line 26: / Line 26: @@
 [[Category: transcriptional cofactor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:29:41 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:31:46 2008''