3h6u: Difference between revisions

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Revision as of 21:31, 14 March 2011

File:3h6u.png

Template:STRUCTURE 3h6u

Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS1493 at 1.85 A resolution

Template:ABSTRACT PUBMED 19591837

About this Structure

3h6u is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  1. Hald H, Ahring PK, Timmermann DB, Liljefors T, Gajhede M, Kastrup JS. Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J Mol Biol. 2009 Sep 4;391(5):906-17. Epub 2009 Jul 8. PMID:19591837 doi:10.1016/j.jmb.2009.07.002
  2. Armstrong N, Gouaux E. Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron. 2000 Oct;28(1):165-81. PMID:11086992
  3. Sun Y, Olson R, Horning M, Armstrong N, Mayer M, Gouaux E. Mechanism of glutamate receptor desensitization. Nature. 2002 May 16;417(6886):245-53. PMID:12015593 doi:10.1038/417245a

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