2w0j: Difference between revisions

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[[Image:2w0j.png|left|200px]]
[[Image:2w0j.png|left|200px]]


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{{STRUCTURE_2w0j|  PDB=2w0j  |  SCENE=  }}  
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===CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH NSC 109555, A SPECIFIC INHIBITOR===
===CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH NSC 109555, A SPECIFIC INHIBITOR===


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{{ABSTRACT_PUBMED_19177354}}
{{ABSTRACT_PUBMED_19177354}}


==About this Structure==
==About this Structure==
[[2w0j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0J OCA].  
[[2w0j]] is a 1 chain structure of [[Serine/threonine protein kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0J OCA].  
 
==See Also==
*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]


==Reference==
==Reference==
<ref group="xtra">PMID:19177354</ref><ref group="xtra">PMID:17616632</ref><references group="xtra"/>
<ref group="xtra">PMID:019177354</ref><ref group="xtra">PMID:017616632</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]

Revision as of 18:48, 26 July 2012

File:2w0j.png

Template:STRUCTURE 2w0j

CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH NSC 109555, A SPECIFIC INHIBITOR

Template:ABSTRACT PUBMED 19177354

About this Structure

2w0j is a 1 chain structure of Serine/threonine protein kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Lountos GT, Tropea JE, Zhang D, Jobson AG, Pommier Y, Shoemaker RH, Waugh DS. Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor. Protein Sci. 2009 Jan;18(1):92-100. PMID:19177354 doi:10.1002/pro.16
  2. Jobson AG, Cardellina JH 2nd, Scudiero D, Kondapaka S, Zhang H, Kim H, Shoemaker R, Pommier Y. Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase. Mol Pharmacol. 2007 Oct;72(4):876-84. Epub 2007 Jul 6. PMID:17616632 doi:10.1124/mol.107.035832

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