2j5y: Difference between revisions

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==Overview==

The albumin-binding domain, or GA module, of the peptostreptococcal, albumin-binding protein expressed in pathogenic strains of Finegoldia, magna is believed to be responsible for the virulence and increased growth, rate of these strains. Here we present the 1.4A crystal structure of this, domain, and compare it with the crystal structure of the GA-albumin, complex. An analysis of protein-protein interactions in the two crystals, and the presence of multimeric GA species in solution, indicate the GA, module is "sticky", and is capable of forming contacts with a range of, protein surfaces. This might lead to interactions with different host, proteins.

The albumin-binding domain, or GA module, of the peptostreptococcal albumin-binding protein expressed in pathogenic strains of Finegoldia magna is believed to be responsible for the virulence and increased growth rate of these strains. Here we present the 1.4A crystal structure of this domain, and compare it with the crystal structure of the GA-albumin complex. An analysis of protein-protein interactions in the two crystals, and the presence of multimeric GA species in solution, indicate the GA module is "sticky", and is capable of forming contacts with a range of protein surfaces. This might lead to interactions with different host proteins.

==About this Structure==

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==Reference==

Crystal structure of a bacterial albumin-binding domain at 1.4A resolution., Cramer JF, Nordberg PA, Hajdu J, Lejon S, FEBS Lett. 2007 ~~Aug~~ 10;581(17):3178-82. Epub 2007 Jun 12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17575979 17575979]

Crystal structure of a bacterial albumin-binding domain at 1.4 A resolution., Cramer JF, Nordberg PA, Hajdu J, Lejon S, FEBS Lett. 2007 Jul 10;581(17):3178-82. Epub 2007 Jun 12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17575979 17575979]

[[Category: Finegoldia magna]]

[[Category: Single protein]]

[[Category: Cramer, J.F.]]

[[Category: Cramer, J F.]]

[[Category: Lejon, S.]]

[[Category: Lundqvist, T.]]

[[Category: Nordberg, P.A.]]

[[Category: Nordberg, P A.]]

[[Category: Valegard, K.]]

[[Category: cell wall]]

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[[Category: protein binding bacterial albumin-binding three-helix bundle]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-The albumin-binding domain, or GA module, of the peptostreptococcal, albumin-binding protein expressed in pathogenic strains of Finegoldia, magna is believed to be responsible for the virulence and increased growth, rate of these strains. Here we present the 1.4A crystal structure of this, domain, and compare it with the crystal structure of the GA-albumin, complex. An analysis of protein-protein interactions in the two crystals, and the presence of multimeric GA species in solution, indicate the GA, module is "sticky", and is capable of forming contacts with a range of, protein surfaces. This might lead to interactions with different host, proteins.
+The albumin-binding domain, or GA module, of the peptostreptococcal albumin-binding protein expressed in pathogenic strains of Finegoldia magna is believed to be responsible for the virulence and increased growth rate of these strains. Here we present the 1.4A crystal structure of this domain, and compare it with the crystal structure of the GA-albumin complex. An analysis of protein-protein interactions in the two crystals, and the presence of multimeric GA species in solution, indicate the GA module is "sticky", and is capable of forming contacts with a range of protein surfaces. This might lead to interactions with different host proteins.
 ==About this Structure==
@@ Line 10: / Line 10: @@
 ==Reference==
-Crystal structure of a bacterial albumin-binding domain at 1.4A resolution., Cramer JF, Nordberg PA, Hajdu J, Lejon S, FEBS Lett. 2007 Aug 10;581(17):3178-82. Epub 2007 Jun 12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17575979 17575979]
+Crystal structure of a bacterial albumin-binding domain at 1.4 A resolution., Cramer JF, Nordberg PA, Hajdu J, Lejon S, FEBS Lett. 2007 Jul 10;581(17):3178-82. Epub 2007 Jun 12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17575979 17575979]
 [[Category: Finegoldia magna]]
 [[Category: Single protein]]
-[[Category: Cramer, J.F.]]
+[[Category: Cramer, J F.]]
 [[Category: Lejon, S.]]
 [[Category: Lundqvist, T.]]
-[[Category: Nordberg, P.A.]]
+[[Category: Nordberg, P A.]]
 [[Category: Valegard, K.]]
 [[Category: cell wall]]
@@ Line 22: / Line 22: @@
 [[Category: protein binding bacterial albumin-binding three-helix bundle]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:34:10 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:59:33 2008''