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==Overview==

Catrocollastatin/vascular apoptosis-inducing protein (VAP)2B is a, metalloproteinase from Crotalus atrox venom, possessing, metalloproteinase/disintegrin/cysteine-rich (MDC) domains that bear the, typical domain architecture of a disintegrin and metalloproteinase, (ADAM)/adamalysin/reprolysin family proteins. Here we describe crystal, structures of catrocollastatin/VAP2B in three different crystal forms, representing the first reported crystal structures of a member of the, monomeric class of this family of proteins. The overall structures show, good agreement with both monomers of atypical homodimeric VAP1. Comparison, of the six catrocollastatin/VAP2B monomer structures and the structures of, VAP1 reveals a dynamic, modular architecture that may be important for the, functions of ADAM/adamalysin/reprolysin family proteins.

Catrocollastatin/vascular apoptosis-inducing protein (VAP)2B is a metalloproteinase from Crotalus atrox venom, possessing metalloproteinase/disintegrin/cysteine-rich (MDC) domains that bear the typical domain architecture of a disintegrin and metalloproteinase (ADAM)/adamalysin/reprolysin family proteins. Here we describe crystal structures of catrocollastatin/VAP2B in three different crystal forms, representing the first reported crystal structures of a member of the monomeric class of this family of proteins. The overall structures show good agreement with both monomers of atypical homodimeric VAP1. Comparison of the six catrocollastatin/VAP2B monomer structures and the structures of VAP1 reveals a dynamic, modular architecture that may be important for the functions of ADAM/adamalysin/reprolysin family proteins.

==About this Structure==

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[[Category: svmp]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:03:16 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Catrocollastatin/vascular apoptosis-inducing protein (VAP)2B is a, metalloproteinase from Crotalus atrox venom, possessing, metalloproteinase/disintegrin/cysteine-rich (MDC) domains that bear the, typical domain architecture of a disintegrin and metalloproteinase, (ADAM)/adamalysin/reprolysin family proteins. Here we describe crystal, structures of catrocollastatin/VAP2B in three different crystal forms, representing the first reported crystal structures of a member of the, monomeric class of this family of proteins. The overall structures show, good agreement with both monomers of atypical homodimeric VAP1. Comparison, of the six catrocollastatin/VAP2B monomer structures and the structures of, VAP1 reveals a dynamic, modular architecture that may be important for the, functions of ADAM/adamalysin/reprolysin family proteins.
+Catrocollastatin/vascular apoptosis-inducing protein (VAP)2B is a metalloproteinase from Crotalus atrox venom, possessing metalloproteinase/disintegrin/cysteine-rich (MDC) domains that bear the typical domain architecture of a disintegrin and metalloproteinase (ADAM)/adamalysin/reprolysin family proteins. Here we describe crystal structures of catrocollastatin/VAP2B in three different crystal forms, representing the first reported crystal structures of a member of the monomeric class of this family of proteins. The overall structures show good agreement with both monomers of atypical homodimeric VAP1. Comparison of the six catrocollastatin/VAP2B monomer structures and the structures of VAP1 reveals a dynamic, modular architecture that may be important for the functions of ADAM/adamalysin/reprolysin family proteins.
 ==About this Structure==
@@ Line 23: / Line 23: @@
 [[Category: svmp]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:34:43 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:03:16 2008''