2uwq: Difference between revisions
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==Overview== | ==Overview== | ||
Proteins of the ASPP family bind to p53 and regulate p53-mediated | Proteins of the ASPP family bind to p53 and regulate p53-mediated apoptosis. Two family members, ASPP1 and ASPP2, have pro-apoptotic functions while iASPP shows anti-apoptotic responses. However, both the mechanism of enhancement/repression of apoptosis and the molecular basis for their different responses remain unknown. To address the role of the N-termini of pro-apoptotic ASPP proteins, we solved the solution structure of N-ASPP2 (1-83) by NMR spectroscopy. The structure of this domain reveals a beta-Grasp ubiquitin-like fold. Our findings suggest a possible role for the N-termini of ASPP proteins in binding to other proteins in the apoptotic response network and thus mediating their selective pro-apoptotic function. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
Solution | Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like fold., Tidow H, Andreeva A, Rutherford TJ, Fersht AR, J Mol Biol. 2007 Aug 24;371(4):948-58. Epub 2007 May 13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17594908 17594908] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Andreeva, A.]] | [[Category: Andreeva, A.]] | ||
[[Category: Fersht, A | [[Category: Fersht, A R.]] | ||
[[Category: Rutherford, T | [[Category: Rutherford, T J.]] | ||
[[Category: Tidow, H.]] | [[Category: Tidow, H.]] | ||
[[Category: ank repeat]] | [[Category: ank repeat]] | ||
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[[Category: ubiquitin-like]] | [[Category: ubiquitin-like]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:51:03 2008'' | ||
