2za5: Difference between revisions

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[[Image:2za5.png|left|200px]]
[[Image:2za5.png|left|200px]]


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{{STRUCTURE_2za5|  PDB=2za5  |  SCENE=  }}  
{{STRUCTURE_2za5|  PDB=2za5  |  SCENE=  }}  


===Crystal Structure of human tryptase with potent non-peptide inhibitor===
===Crystal Structure of human tryptase with potent non-peptide inhibitor===


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{{ABSTRACT_PUBMED_18272363}}
{{ABSTRACT_PUBMED_18272363}}


==About this Structure==
==About this Structure==
[[2za5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZA5 OCA].  
[[2za5]] is a 4 chain structure of [[Tryptase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZA5 OCA].  
 
==See Also==
*[[Tryptase|Tryptase]]


==Reference==
==Reference==
<ref group="xtra">PMID:18272363</ref><ref group="xtra">PMID:12930148</ref><references group="xtra"/>
<ref group="xtra">PMID:018272363</ref><ref group="xtra">PMID:012930148</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Tryptase]]
[[Category: Tryptase]]

Revision as of 15:47, 25 July 2012

File:2za5.png

Template:STRUCTURE 2za5

Crystal Structure of human tryptase with potent non-peptide inhibitor

Template:ABSTRACT PUBMED 18272363

About this Structure

2za5 is a 4 chain structure of Tryptase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Costanzo MJ, Yabut SC, Zhang HC, White KB, de Garavilla L, Wang Y, Minor LK, Tounge BA, Barnakov AN, Lewandowski F, Milligan C, Spurlino JC, Abraham WM, Boswell-Smith V, Page CP, Maryanoff BE. Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2114-21. Epub 2008 Jan 30. PMID:18272363 doi:10.1016/j.bmcl.2008.01.093
  2. Costanzo MJ, Yabut SC, Almond HR Jr, Andrade-Gordon P, Corcoran TW, De Garavilla L, Kauffman JA, Abraham WM, Recacha R, Chattopadhyay D, Maryanoff BE. Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone. J Med Chem. 2003 Aug 28;46(18):3865-76. PMID:12930148 doi:https://dx.doi.org/10.1021/jm030050p

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