3b3k: Difference between revisions

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[[Image:3b3k.png|left|200px]]
[[Image:3b3k.png|left|200px]]


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{{STRUCTURE_3b3k|  PDB=3b3k  |  SCENE=  }}  
{{STRUCTURE_3b3k|  PDB=3b3k  |  SCENE=  }}  


===Crystal structure of the complex between PPARgamma and the full agonist LT175===
===Crystal structure of the complex between PPARgamma and the full agonist LT175===


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==See Also==
==See Also==
*[[Peroxisome Proliferator-Activated Receptors]]
*[[Peroxisome Proliferator-Activated Receptors|Peroxisome Proliferator-Activated Receptors]]


==Reference==
==Reference==
<ref group="xtra">PMID:19053776</ref><ref group="xtra">PMID:9744270</ref><ref group="xtra">PMID:10882139</ref><ref group="xtra">PMID:11698662</ref><references group="xtra"/>
<ref group="xtra">PMID:019053776</ref><ref group="xtra">PMID:009744270</ref><ref group="xtra">PMID:010882139</ref><ref group="xtra">PMID:011698662</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Crestani, M.]]
[[Category: Crestani, M.]]
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[[Category: Pochetti, G.]]
[[Category: Pochetti, G.]]
[[Category: Activator]]
[[Category: Activator]]
[[Category: Alternative splicing]]
[[Category: Bundle of alpha-helice]]
[[Category: Bundle of alpha-helice]]
[[Category: Diabetes mellitus]]
[[Category: Diabetes mellitus]]
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[[Category: Obesity]]
[[Category: Obesity]]
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Polymorphism]]
[[Category: Receptor]]
[[Category: Receptor]]
[[Category: Small four-strnded beta-sheet]]
[[Category: Small four-strnded beta-sheet]]
[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]

Revision as of 13:13, 26 July 2012

File:3b3k.png

Template:STRUCTURE 3b3k

Crystal structure of the complex between PPARgamma and the full agonist LT175

Template:ABSTRACT PUBMED 19053776

About this Structure

3b3k is a 2 chain structure of Peroxisome Proliferator-Activated Receptors with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Montanari R, Saccoccia F, Scotti E, Crestani M, Godio C, Gilardi F, Loiodice F, Fracchiolla G, Laghezza A, Tortorella P, Lavecchia A, Novellino E, Mazza F, Aschi M, Pochetti G. Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design. J Med Chem. 2008 Dec 25;51(24):7768-76. PMID:19053776 doi:10.1021/jm800733h
  2. Nolte RT, Wisely GB, Westin S, Cobb JE, Lambert MH, Kurokawa R, Rosenfeld MG, Willson TM, Glass CK, Milburn MV. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. Nature. 1998 Sep 10;395(6698):137-43. PMID:9744270 doi:10.1038/25931
  3. Gampe RT Jr, Montana VG, Lambert MH, Miller AB, Bledsoe RK, Milburn MV, Kliewer SA, Willson TM, Xu HE. Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors. Mol Cell. 2000 Mar;5(3):545-55. PMID:10882139
  4. Xu HE, Lambert MH, Montana VG, Plunket KD, Moore LB, Collins JL, Oplinger JA, Kliewer SA, Gampe RT Jr, McKee DD, Moore JT, Willson TM. Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13919-24. Epub 2001 Nov 6. PMID:11698662 doi:10.1073/pnas.241410198

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