1wut: Difference between revisions
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[[Image:1wut.png|left|200px]] | [[Image:1wut.png|left|200px]] | ||
{{STRUCTURE_1wut| PDB=1wut | SCENE= }} | {{STRUCTURE_1wut| PDB=1wut | SCENE= }} | ||
===Acyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes=== | ===Acyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes=== | ||
{{ABSTRACT_PUBMED_15987904}} | {{ABSTRACT_PUBMED_15987904}} | ||
==About this Structure== | ==About this Structure== | ||
[[1wut]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUT OCA]. | [[1wut]] is a 1 chain structure of [[Glycogen Phosphorylase]] with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUT OCA]. | ||
==See Also== | |||
*[[Glycogen Phosphorylase|Glycogen Phosphorylase]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:015987904</ref><ref group="xtra">PMID:010873856</ref><ref group="xtra">PMID:009384557</ref><ref group="xtra">PMID:010980448</ref><ref group="xtra">PMID:014592521</ref><references group="xtra"/> | ||
[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
[[Category: Phosphorylase]] | [[Category: Phosphorylase]] | ||
Revision as of 23:18, 25 July 2012
Acyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes
Template:ABSTRACT PUBMED 15987904
About this Structure
1wut is a 1 chain structure of Glycogen Phosphorylase with sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.
See Also
Reference
- Oikonomakos NG, Kosmopoulou MN, Chrysina ED, Leonidas DD, Kostas ID, Wendt KU, Klabunde T, Defossa E. Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs. Protein Sci. 2005 Jul;14(7):1760-71. PMID:15987904 doi:14/7/1760
- Oikonomakos NG, Skamnaki VT, Tsitsanou KE, Gavalas NG, Johnson LN. A new allosteric site in glycogen phosphorylase b as a target for drug interactions. Structure. 2000 Jun 15;8(6):575-84. PMID:10873856
- Zographos SE, Oikonomakos NG, Tsitsanou KE, Leonidas DD, Chrysina ED, Skamnaki VT, Bischoff H, Goldmann S, Watson KA, Johnson LN. The structure of glycogen phosphorylase b with an alkyldihydropyridine-dicarboxylic acid compound, a novel and potent inhibitor. Structure. 1997 Nov 15;5(11):1413-25. PMID:9384557
- Rath VL, Ammirati M, Danley DE, Ekstrom JL, Gibbs EM, Hynes TR, Mathiowetz AM, McPherson RK, Olson TV, Treadway JL, Hoover DJ. Human liver glycogen phosphorylase inhibitors bind at a new allosteric site. Chem Biol. 2000 Sep;7(9):677-82. PMID:10980448
- Lu Z, Bohn J, Bergeron R, Deng Q, Ellsworth KP, Geissler WM, Harris G, McCann PE, McKeever B, Myers RW, Saperstein R, Willoughby CA, Yao J, Chapman K. A new class of glycogen phosphorylase inhibitors. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4125-8. PMID:14592521
