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'''PPAR α'''

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[[Peroxisome Proliferator-Activated Receptors]](PPARs) consist of a superfamily of nuclear hormone receptors that act as transcription factors. PPARs are ligand-activated transcription factors that govern numerous biological processes, including energy metabolism, cell proliferation and inflammation [1]. PPAR-alpha is one of the three PPAR isotypes (alpha, beta and gamma), which can be distinguished by its activating ligand and its specific PPAR-regulated genes to which it provides transcriptional control.  PPAR-alpha has an important role in the regulation of nutrient metabolism, including fatty acid oxidation, gluconeogenesis and amino acid metabolism [2]. PPAR-alpha is predominately expressed in tissues with high rates of mitochondrial beta oxidation, such as liver, heart, muscle, kidney and cells of the arterial wall [3]. Various activating molecules of PPAR alpha have consisted of fibrates, fatty acids and eicosanoids, 15-d Ptg (15-Deoxy-Delta Prostaglandin-J2) and oxidized fatty acids. As PPAR-alpha (as well as the other associated isotypes) has an important role in the regulation of energy metabolism, and as its activity can be manipulated by various drugs, there is an increasing interest in the potential connection between PPAR alpha and obesity [1].