Nitric Oxide Synthase: Difference between revisions

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Nitric Oxide Synthase (NOS) is an enzyme catalysing the formation of L-citrulline and [http://en.wikipedia.org/wiki/Nitric_Oxide/ nitric oxide] (NO) from L-arginine. NOS is a homodimeric protein with 125- to 160-kDa per monomer.
Nitric Oxide Synthase (NOS) is an enzyme catalysing the formation of L-citrulline and [http://en.wikipedia.org/wiki/Nitric_Oxide/ nitric oxide] (NO) from L-arginine. NOS is a homodimeric protein with 125- to 160-kDa per monomer.
'''(See also [[Nitric Oxide Synthase (Part II)]])'''
=Introduction=
=Introduction=


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'''Nitric Oxide Synthase''' (NOS) is an enzyme which catalyzes the production of the signaling molecule NO from arginine.  In mammals, NOS appears as 3 isozymes: neuronal NOS (nNOS), cytokine-inducible NOS (iNOS) and endothelial NOS (eNOS).  The N-terminal domain of NOS is an oxygenase domain (OD).  NOS cofactors are: NADPH, FAD, FMN, heme and O2. The images at the left and at the right correspond to one representative NOS, ''i.e.'' the crystal structure of Nitric Oxide Synthase from ''Bacillus subtilis'' ([[2amo]]).
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== 3D Structures of Nitric Oxide Synthase ==
===Endothelial NOS===
[[3nld]], [[3nle]], [[3nlf]], [[3nlg]], [[3jww]], [[3jwx]], [[3jwy]], [[3jwz]], [[3dqs]], [[3dqt]] – b-eNOS OD+pyrrolidinomethyl aminopyridine derivative – bovine<br />
[[1dm6]] – b-eNOS OD+guanidine derivative<br />
[[3nlh]] – b-eNOS OD (mutant)+pyrrolidinomethyl aminopyridine derivative<br />
[[3e7s]] – b-eNOS OD+inhibitor<br />
[[1rs8]], [[1rs9]] – b-eNOS OD +dipeptide inhibitor<br />
[[1nse]] – b-eNOS OD<br />
[[1p6n]] – b-eNOS OD +dipeptide inhibitor<br />
[[5nse]], [[1fol]], [[1foo]], [[1fop]], [[1dm7]], [[2nse]], [[3nse]], [[4nse]] – b-eNOS OD+arginine derivative<br />
[[6nse]] – b-eNOS OD+canavanine<br />
[[7nse]] – b-eNOS OD+ADMA<br />
[[1i83]], [[1d1v]], [[1d1x]], [[1d1y]], [[1ed4]], [[9nse]] – b-eNOS OD+urea derivative<br />
[[1dmj]], [[1dmk]] – b-eNOS OD+pterin derivative<br />
[[1foi]], [[1dmi]] – b-eNOS OD+inhibitor<br />
[[1d0c]], [[8nse]], [[1foj]], [[1ed5]] – b-eNOS OD+indazole derivative<br />
[[1dm8]] – b-eNOS OD+triazole derivative<br />
[[1ed6]] – b-eNOS OD+NO<br />
[[1q2o]] – b-eNOS OD (mutant)+dipeptide inhibitor<br />
[[1p6l]], [[1p6m]] – r-eNOS OD +dipeptide inhibitor<br />
[[3eah]] – h-eNOS OD - human<br />
[[3nos]] – h-eNOS OD+arginine<br />
[[1m9j]] – h-eNOS OD+chlorzoxazone<br />
[[1m9k]], [[1m9r]] – h-eNOS OD+indazole derivative<br />
===Neuronal NOS===
[[2hx2]] – b-nNOS OD+nitroguanidine derivative<br />
[[3nli]], [[3nlj]], [[3nlk]], [[3nln]], [[3nlo]], [[3nlp]], [[3nlq]], [[3nlr]], [[3jws]], [[3jwt]], [[3jwu]], [[3jwv]], [[3jx0]], [[3jx1]], [[3jx2]], [[3jx3]], [[3jx4]], [[3jx5]], [[3jx6]], [[3dqr]] – r-nNOS OD (mutant)+pyrrolidinomethyl aminopyridine derivative – rat<br />
[[3nlm]], [[3nny]], [[3nnz]], [[3n2r]], [[3b3o]], [[3b3p]], [[3b3m]], [[3b3n]] – r-nNOS OD+pyrrolidinomethyl aminopyridine derivative<br />
[[2hx3]] – r-nNOS OD+nitroguanidine derivative<br />
[[2hx4]], [[1zvl]] – r-nNOS OD+arginine derivative<br />
[[1om4]], [[1k2r]], [[1k2s]], [[1lzx]] – r-nNOS OD+arginine derivative<br />
[[1k2t]], [[1k2u]] – r-nNOS OD+thiourea derivative<br />
[[1om5]] – r-nNOS OD+indazole derivative<br />
[[1lzz]], [[1m00]] – r-nNOS OD+guanidine derivative<br />
[[3fc5]], [[1zvi]] – r-nNOS OD<br />
[[1qw6]] – r-nNOS OD+arginine derivative<br />
[[1qwc]] – r-nNOS OD+inhibitor<br />
[[3jt3]], [[3jt4]], [[3jt5]], [[3jt6]], [[3jt7]], [[3jt8]], [[3jt9]], [[3jta]] – r-nNOS OD+ornithine derivative<br />
[[3hsn]] – r-nNOS OD+NHA+CO<br />
[[3hso]], [[3hsp]] -  r-nNOS OD+NHA+NO<br />
[[2g6h]], [[2g6i]], [[2g6j]] – r-nNOS OD+pterin derivative<br />
[[2g6k]], [[2g6l]] – r-nNOS OD+pterin derivative+NO<br />
[[2g6m]], [[2g6n]], [[2g6o]] – r-nNOS OD+pterin derivative+CO<br />
[[1zzq]], [[1zzr]], [[1zzs]], [[1zzt]], [[1zzu]] – r-nNOS OD (mutant)+dipeptide inhibitor<br />
[[1rs6]], [[1rs7]], [[1p6h]], [[1p6i]], [[1p6j]] – r-nNOS OD +dipeptide inhibitor<br />
[[1mmv]], [[1mmw]] – r-nNOS OD + inhibitor<br />
[[1p6k]] – r-nNOS OD (mutant)+dipeptide inhibitor<br />
[[1vag]] – m-nNOS OD+inhibitor - mouse<br />
===Inducible NOS===
[[3nqs]], [[3e65]] – m-iNOS OD + pterin derivative<br />
[[1jwj]], [[1jwk]] – m-iNOS OD (mutant)+ pterin derivative<br />
[[2bhj]] – m-iNOS OD+coumarin<br />
[[3eai]], [[3ebd]], [[3ebf]], [[1r35]], [[2nod]] – m-iNOS OD+pterin derivative<br />
[[3nod]] – m-iNOS OD+product analog<br />
[[1noc]] – m-iNOS OD+chloramphenicol acetyltransferase<br />
[[3e67]] – m-iNOS OD+4-MAP<br />
[[3e68]], [[3e6l]], [[3e6n]], [[3e6o]], [[3e6t]], [[3e7i]], [[3e7m]], [[3e7t]], [[1vaf]], [[1qw5]], [[1dd7]] – m-iNOS OD+inhibitor <br />
[[2orq]], [[2orr]], [[2ors]], [[2ort]], [[2oro]], [[2orp]], [[1nos]] – m-iNOS OD+imidazole derivative<br />
[[3dwj]] – m-iNOS OD (mutant)<br />
[[1qw4]], [[1dwv]], [[1dww]], [[1dwx]], [[1nod]] – m-iNOS OD+arginine derivative<br />
[[2nos]] – m-iNOS OD+guanidine derivative<br />
[[1n2n]] – m-iNOS OD+CN<br />
[[1m9t]] – m-iNOS OD+indazole derivative<br />
[[1m8d]] – m-iNOS OD+chlorzoxazone<br />
[[1m8e]], [[1m8h]], [[1m8i]], [[1m9m]], [[1m9q]] – m-iNOS OD+ indazole derivative<br />
[[3hr4]] – h-iNOS residues 503-715+calmodulin – human<br />
[[3e7g]] – h-iNOS residues 82-505+inhibitor<br />
[[3ej8]] – h-iNOS OD+imidazole<br />
[[4nos]] – h-iNOS OD+inhibitor<br />
[[4nsi]] – h-iNOS OD+arginine<br />
[[2nsi]] – h-iNOS OD+thiourea derivative<br />
===Prokaryote NOS===
[[2amo]] – BsNOS – ''Bacillus subtilis''<br />
[[2an0]], [[2an2]] – BsNOS (mutant)<br />
[[2fbz]], [[2fc2]], [[2fc1]] – BsNOS+NO<br />
[[1m7v]], [[1m7z]] – BsNOS+THF+arginine<br />
[[2flq]] – NOS+arginine – ''Geobacillus stearothermophilus''<br />


==References==
==References==
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