Sandbox Reserved 321

This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada.

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InhA

by Kelly Hrywkiw

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D load='2h9i' size='350' frame='false' scene=
2h9i, resolution 2.20Å (default scene)
Ligands:	EAD
Gene:	inhA (Mycobacterium tuberculosis)
Activity:	[acyl-carrier-protein_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number 1.3.1.9
Related:	1zid
Structural annotation: Resources: InterPro : Ipr014358, Ipr002198 UniProt : P0A5Y6
Functional annotation: Biological process: lipid biosynthetic process response to antibiotic fatty acid biosynthetic process metabolic process Molecular function: enoyl-[acyl-carrier-protein reductase (NADH) activity] oxidoreductase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

Introduction

InhA is a enoyl-acyl ACP carrier protein that plays a role in the sysnthesis of Mycolic Acid

References

<Wang F., Langley R., Gulten G., Dover L. G., Besra G. S., Jacobs W. R., and Sacchettini J. C., 2007. The Journal of Experimental Medicine. 204(1) 73-78="mech of thioamide drug action"/>