Sandbox Reserved 323: Difference between revisions
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==Ligand Interactions== | ==Ligand Interactions== | ||
[[Image: | [[Image: PPARa_LBD.jpeg|375px|left|thumb|Figure 1: Three-dimensional crystal structure of PPARα complexed to a chemical agonist and coactivator peptide <ref>PMID:15661858</ref>]] | ||
PPAR alpha ligands can consist of either synthetic drugs (exogenous) or biological molecules (endogenous). Most common biological molecules that serve as ligands for human PPAR alpha are fatty acids, fatty acid derivatives <ref name="PPAR1"/><ref name="PPAR2"/>. Several enzymes such as 8-, 12-, 15-, and 5-lipoxygenases, the cyclooxygenases and cytochrome P450 utilize fatty acids as substrates to produce putative PPAR alpha ligands. Leukotriene B4 is a well-known putative PPAR alpha ligand, as well as 19- and 20- hydroxyeicosatetraeonic acid, generated from cytochrome P450 as a conversion of arachidonic acid. Oleylethanolamide, a naturally occurring lipid, has also been identified as a high affinity PPAR alpha ligand regulating PPAR alpha activity and lipid metabolism <ref name="PPAR6">PMID:20414453</ref>. | PPAR alpha ligands can consist of either synthetic drugs (exogenous) or biological molecules (endogenous). Most common biological molecules that serve as ligands for human PPAR alpha are fatty acids, fatty acid derivatives <ref name="PPAR1"/><ref name="PPAR2"/>. Several enzymes such as 8-, 12-, 15-, and 5-lipoxygenases, the cyclooxygenases and cytochrome P450 utilize fatty acids as substrates to produce putative PPAR alpha ligands. Leukotriene B4 is a well-known putative PPAR alpha ligand, as well as 19- and 20- hydroxyeicosatetraeonic acid, generated from cytochrome P450 as a conversion of arachidonic acid. Oleylethanolamide, a naturally occurring lipid, has also been identified as a high affinity PPAR alpha ligand regulating PPAR alpha activity and lipid metabolism <ref name="PPAR6">PMID:20414453</ref>. | ||
