Sandbox Reserved 350: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 13: Line 13:
The structure of Human Coagulation Factor V (FV) is sculpted from, originates from, precursors from a polypeptide to a A1-A2-B-A3-C1-C2 layout which results in the activated (FVa) protein.   
The structure of Human Coagulation Factor V (FV) is sculpted from, originates from, precursors from a polypeptide to a A1-A2-B-A3-C1-C2 layout which results in the activated (FVa) protein.   
<br />
<br />
FVa consists of a conserved '''β-Barrel framework''' acting as a scaffold for three loops and a '''C2 domain'''.
<br />
'''-Heavy A1-A2 Chain'''
'''-Heavy A1-A2 Chain'''
<br />
<br />
'''-Light A3-C1-C2 Chain'''
'''-Light A3-C1-C2 Chain'''
<br />
FVa consists of a conserved '''β-Barrel framework''' acting as a scaffold for three loops and a '''C2 domain''' (FVa-C2).
<br />
'''The FVa-C2''', which is classified as a '''distorted jelly-roll β-barrel motif''', is compossed of e'''ight major antiparallel strands''' arranged into two '''β-sheets of five and three strands''' packed against one another.
<br />
The overall Barrel structure is closed at the top and bottom by '''three''' and '''two''' straight segments, giving it an '''overall spherical shape''' with a flattened upper surface.
<br />
<br />
<br />
Which once activated, enhances the ability of factor Xa to generate α-thrombin from prothrombin (5-Fold).
Which once activated, enhances the ability of factor Xa to generate α-thrombin from prothrombin (5-Fold).

Revision as of 04:46, 16 March 2011

This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Introduction

Protein: cHuman Coagulation factor V, 1czv [1]
Drag the structure with the mouse to rotate
1czv, resolution 2.40Å (default scene)
Related: 1czs, 1czt
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Structure

The structure of Human Coagulation Factor V (FV) is sculpted from, originates from, precursors from a polypeptide to a A1-A2-B-A3-C1-C2 layout which results in the activated (FVa) protein.
-Heavy A1-A2 Chain
-Light A3-C1-C2 Chain
FVa consists of a conserved β-Barrel framework acting as a scaffold for three loops and a C2 domain (FVa-C2).
The FVa-C2, which is classified as a distorted jelly-roll β-barrel motif, is compossed of eight major antiparallel strands arranged into two β-sheets of five and three strands packed against one another.
The overall Barrel structure is closed at the top and bottom by three and two straight segments, giving it an overall spherical shape with a flattened upper surface.


Which once activated, enhances the ability of factor Xa to generate α-thrombin from prothrombin (5-Fold).




i am coloring by.... by chain



Function

Free
Free
aaaa
aaaa

Interactions







References

  1. ↑ 10586886
Retrieved from "https://proteopedia.org/index.php?title=Sandbox_Reserved_350&oldid=1213638"