Sandbox Reserved 350: Difference between revisions

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'''The Three Loops'''

(1)-Ser21-Trp31; Apex containing Indole moieties able to form hydrogen bonds (Two consecutive Trp's 26 & 27).

(1)-Ser21-Trp31; Apex containing Indole moieties able to form hydrogen bonds (Two consecutive Trp 26 & 27).

(2)-Asn39-Asn45; Apex capped with a basic residue able to form hydrogen bonds (~~Arg 43~~.

(2)-Asn39-Asn45; Apex capped with a basic residue able to form hydrogen bonds (Arg43).

(3)-Gly75-Tyr84; Apex Hydrophobic (~~Leu 79~~).

(3)-Gly75-Tyr84; Apex Hydrophobic (Leu79).

~~All~~ are described by ''Authors of the paper'' to protrude like spikes from the bottom of the barrel in monomeric FVa-C2. It is also worth noting that spike (1) & spike (3) are separated by β-hairpin structures and spike (2) is described as a wider irregularly loop comparatively. These three loops extending from the C2 domain, are all linked to each other, and to '''three shorter loops''' by an intricate '''H-bonding network''' which extends to residues at the bottom of the β-barrel.

The apexes of these three loops within the C2 domain, are able to create a deep groove lined by hydrophobic (Trp31, Met83) and polar residues (Gln48, Ser78), as seen and xxxx the '''"Open Form"''' of FVa-C2.

A second dimeric crystal form of FVa-C2, packed through the free edges of S6 strands, presenting a different Leu104-Val109

loop, suggesting capabilities of adopting a "Closed Form".

The three loops are described by ''Authors of the paper'' to protrude like spikes from the bottom of the barrel in monomeric FVa-C2. It is also worth noting that spike (1) & spike (3) are separated by β-hairpin structures and spike (2) is described as a wider irregularly loop comparatively. These three loops extending from the C2 domain, are all linked to each other, and to '''three shorter loops''' by an intricate '''H-bonding network''' which extends to residues at the bottom of the β-barrel.

The overall Barrel structure is closed at the top and bottom by '''three''' and '''two''' straight segments, giving it an '''overall spherical shape''' with a flattened upper surface.

Sandbox Reserved 350: Difference between revisions

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@@ Line 25: / Line 25: @@
 '''The Three Loops'''
 <br />
-(1)-Ser21-Trp31; Apex containing Indole moieties able to form hydrogen bonds (Two consecutive Trp's 26 & 27).
+(1)-Ser21-Trp31; Apex containing Indole moieties able to form hydrogen bonds (Two consecutive Trp 26 & 27).
 <br />
-(2)-Asn39-Asn45; Apex capped with a basic residue able to form hydrogen bonds (Arg 43.
+(2)-Asn39-Asn45; Apex capped with a basic residue able to form hydrogen bonds (Arg43).
 <br />
-(3)-Gly75-Tyr84; Apex Hydrophobic (Leu 79).
+(3)-Gly75-Tyr84; Apex Hydrophobic (Leu79).
-All are described by ''Authors of the paper'' to protrude like spikes from the bottom of the barrel in monomeric FVa-C2.  It is also worth noting that spike (1) & spike (3) are separated by β-hairpin structures and spike (2) is described as a wider irregularly loop comparatively.  These three loops extending from the C2 domain, are all linked to each other, and to '''three shorter loops''' by an intricate '''H-bonding network''' which extends to residues at the bottom of the β-barrel.
+<br />
+The apexes of these three loops within the C2 domain, are able to create a deep groove lined by hydrophobic (Trp31, Met83) and polar residues (Gln48, Ser78), as seen and xxxx the '''"Open Form"''' of FVa-C2.
+<br />
+A second dimeric crystal form of FVa-C2, packed through the free edges of S6 strands, presenting a different Leu104-Val109
+loop, suggesting capabilities of adopting a "Closed Form".
+<br />
+The three loops are described by ''Authors of the paper'' to protrude like spikes from the bottom of the barrel in monomeric FVa-C2.  It is also worth noting that spike (1) & spike (3) are separated by β-hairpin structures and spike (2) is described as a wider irregularly loop comparatively.  These three loops extending from the C2 domain, are all linked to each other, and to '''three shorter loops''' by an intricate '''H-bonding network''' which extends to residues at the bottom of the β-barrel.
 The overall Barrel structure is closed at the top and bottom by '''three''' and '''two''' straight segments, giving it an '''overall spherical shape''' with a flattened upper surface.
 <br />