Reserved Sandbox 329: Difference between revisions

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== INTRODUCTION ==
== INTRODUCTION ==


Terminal uridylyl transferases (TUTases) belong to a superfamily of polymerase ß nucleotidyl transferases.<ref>PMID:17785418</ref> TUTases have been isolated from ''Trypanosoma brucei'' and also ''Leishmania ssp'', parasites causing diseases in humans such as African Sleeping Sickness.<ref>PMID:11893335</ref>
Terminal uridylyl transferases (TUTases) belong to a superfamily of polymerase ß nucleotidyl transferases.<ref name="1">PMID:17785418</ref> TUTases have been isolated from ''Trypanosoma brucei'' and also ''Leishmania ssp'', parasites causing diseases in humans such as African Sleeping Sickness.<ref>PMID:11893335</ref> Trypanosomal TUTases have RNA substrates that are shown to select for cognate nucleosides and provide a metal ion binding site for Mg<sup>2+</sup> ions. TUTases function in RNA editing; they add UMP to the 3' hydroxyl group.<ref name="1">PMID:17785418</ref>




Revision as of 17:14, 16 March 2011

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2q0d, resolution 2.00Å (default scene)
Ligands: ATP, MG
Gene: TUT4 (Trypanosoma brucei)
Activity: RNA uridylyltransferase, with EC number 2.7.7.52
Related: 2ikf, 2nom
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Uridylyl transferases

INTRODUCTION

Terminal uridylyl transferases (TUTases) belong to a superfamily of polymerase ß nucleotidyl transferases.Cite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title TUTases have been isolated from Trypanosoma brucei and also Leishmania ssp, parasites causing diseases in humans such as African Sleeping Sickness.[1] Trypanosomal TUTases have RNA substrates that are shown to select for cognate nucleosides and provide a metal ion binding site for Mg2+ ions. TUTases function in RNA editing; they add UMP to the 3' hydroxyl group.Cite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title


The bound ligand is an ATP complex with two Mg2+ ions.



References

  1. ↑ Aphasizhev R, Sbicego S, Peris M, Jang SH, Aphasizheva I, Simpson AM, Rivlin A, Simpson L. Trypanosome mitochondrial 3' terminal uridylyl transferase (TUTase): the key enzyme in U-insertion/deletion RNA editing. Cell. 2002 Mar 8;108(5):637-48. PMID:11893335

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