Sandbox Reserved 309: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Hezzy Cody (talk | contribs) No edit summary |
Hezzy Cody (talk | contribs) No edit summary |
||
| Line 2: | Line 2: | ||
{{Template:Sandbox_Reserved_BCMB307}} | {{Template:Sandbox_Reserved_BCMB307}} | ||
<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | <!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
{{STRUCTURE_2cdn|PDB=2cdn|SCENE=}} | |||
__TOC__ | __TOC__ | ||
=Introduction/General Information= | =Introduction/General Information= | ||
Adenylate kinase is a phosphotransferase that catalyzes the interconversion reaction of ATP, ADP, and AMP. It is part of the nucleotide and nucleoside kinases family. Its source is the Myobacterium tuberculosis bacterium. Since Adenylate Kinase is found to be essential for bacterial survival, it is targeted by drugs when treating the disease. <ref name=Bellinzoni>PMID: 16672241 </ref> | Adenylate kinase is a phosphotransferase that catalyzes the interconversion reaction of ATP, ADP, and AMP. It is part of the nucleotide and nucleoside kinases family. Its source is the Myobacterium tuberculosis bacterium. Since Adenylate Kinase is found to be essential for bacterial survival, it is targeted by drugs when treating the disease. <ref name=Bellinzoni>PMID: 16672241 </ref> | ||
=Structure= | =Structure= | ||
Protein of 201 residues with a <scene name='Sandbox_Reserved_309/Ligand/1'>Ligand</scene> | Protein of 201 residues with a <scene name='Sandbox_Reserved_309/Ligand/1'>Ligand</scene> consisting of two molecules of ADP (Adenosine-5'-Phosphate) and Magnesium ion. | ||
==The solution structure== | ==The solution structure== | ||
With no ligand, is represented by a central CORE domain composed of a 5-stranded parallel beta sheet surrounded by 7 alpha helices, and two periferal domains, LID and NMP <ref name=Miron>PMID:14705932 </ref> | With no ligand, is represented by a central CORE domain composed of a 5-stranded parallel beta sheet surrounded by 7 alpha helices, and two periferal domains, LID and NMP <ref name=Miron>PMID:14705932 </ref> | ||
| Line 17: | Line 16: | ||
=Catalytic Mechanism= | =Catalytic Mechanism= | ||
ADP+MgADP↔MgATP+AMP | ADP+MgADP↔MgATP+AMP | ||
=References= | |||
<references/> | |||
*bullet | *bullet | ||
**subbullet | **subbullet | ||
| Line 22: | Line 25: | ||
<Structure load=2cdn size='200' frame='true' align='left' caption= 'Adenosine-5'-Diphosphate and Mg' scene='Sandbox_Reserved_309/Ligand/1'/> | <Structure load=2cdn size='200' frame='true' align='left' caption= 'Adenosine-5'-Diphosphate and Mg' scene='Sandbox_Reserved_309/Ligand/1'/> | ||
α | α | ||
