Lipase: Difference between revisions
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<applet load='1hpl3.pdb' size='300' frame='true' align='right' scene="Lipase/Lipase_starting_scene/2" caption='Crystal Structure of Horse Pancreatic Lipase, [[1hpl]]' /> | <applet load='1hpl3.pdb' size='300' frame='true' align='right' scene="Lipase/Lipase_starting_scene/2" caption='Crystal Structure of Horse Pancreatic Lipase complex with Ca ion, [[1hpl]]' /> | ||
'''Lipase''' is a subclass of esterases which catalyzes the hydrolysis of ester bonds in lipid substrates and is essential for fat digestion. It is primarily produced in the pancreas, but can be found in the mouth and stomach as well. The <scene name='Lipase/Lipase_starting_scene/2'>lipase</scene> typically digests fat lipids into monoglycerides and free fatty acids, with the resulting monomers subsequently shuttled to the small intestine and eventually absorbed into the lymphatic system. | '''Lipase''' is a subclass of esterases which catalyzes the hydrolysis of ester bonds in lipid substrates and is essential for fat digestion. It is primarily produced in the pancreas, but can be found in the mouth and stomach as well. The <scene name='Lipase/Lipase_starting_scene/2'>lipase</scene> typically digests fat lipids into monoglycerides and free fatty acids, with the resulting monomers subsequently shuttled to the small intestine and eventually absorbed into the lymphatic system. | ||
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== 3D Structures of Lipase == | == 3D Structures of Lipase == | ||
''Update June 2011'' | |||
===Eukaryote natives: === | ===Eukaryote natives: === | ||
[[1hpl]] – hLip – horse <br /> | [[1hpl]] – hLip – horse <br /> | ||
[[1hlg]] – hLip – human - gastric<br /> | [[1hlg]] – hLip – human - gastric<br /> | ||
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[[2ory]] – Lip – ''Photobacterium lypoliticum''<br /> | [[2ory]] – Lip – ''Photobacterium lypoliticum''<br /> | ||
[[2z5g]], [[2dsn]] – Lip T1 – ''Geobacillus zalihae''<br /> | [[2z5g]], [[2dsn]] – Lip T1 – ''Geobacillus zalihae''<br /> | ||
[[3p94]] – Lip – ''Parabacteroides distasonis'' | [[3p94]] – Lip – ''Parabacteroides distasonis''<br /> | ||
[[3ngm]] – Lip – ''Gibberella zeae'' | |||
===Lipase/colipase complexes. The colipase is a co-enzyme whose binding to lipase optimizes the enzymatic activity=== | ===Lipase/colipase complexes. The colipase is a co-enzyme whose binding to lipase optimizes the enzymatic activity=== | ||
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===Lipase conjugated with analogs to its reaction intermediates=== | ===Lipase conjugated with analogs to its reaction intermediates=== | ||
[[1lpn]] – CrLip+ | [[1lpn]], [[1lpo]], [[1lpp]] – CrLip+ esulfonates <br /> | ||
[[ | [[3rar]] – CrLip+ phosphoonate <br /> | ||
[[1qz3]] – EaEst2(mutant) (LIPE)+hexadecanesulfonate <br /> | [[1qz3]] – EaEst2(mutant) (LIPE)+hexadecanesulfonate <br /> | ||
