2p83: Difference between revisions
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==Overview== | ==Overview== | ||
The design and synthesis of a novel series of potent BACE1 | The design and synthesis of a novel series of potent BACE1 hydroxyethylamine inhibitors. These inhibitors feature hydrogen bonding substituents at the C-5 position of the isophthalamide ring with improved selectivity over cathepsin D. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
Potent and selective isophthalamide | Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1., Kortum SW, Benson TE, Bienkowski MJ, Emmons TL, Prince DB, Paddock DJ, Tomasselli AG, Moon JB, LaBorde A, TenBrink RE, Bioorg Med Chem Lett. 2007 Jun 15;17(12):3378-83. Epub 2007 Apr 3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17434734 17434734] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Benson, T | [[Category: Benson, T E.]] | ||
[[Category: Emmons, T | [[Category: Emmons, T L.]] | ||
[[Category: Paddock, D | [[Category: Paddock, D J.]] | ||
[[Category: Prince, D | [[Category: Prince, D B.]] | ||
[[Category: Tomasselli, A | [[Category: Tomasselli, A G.]] | ||
[[Category: MR0]] | [[Category: MR0]] | ||
[[Category: PO4]] | [[Category: PO4]] | ||
[[Category: protein-inhibitor complex]] | [[Category: protein-inhibitor complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:26:53 2008'' | ||
