3l2y: Difference between revisions
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{{STRUCTURE_3l2y| PDB=3l2y | SCENE= }} | {{STRUCTURE_3l2y| PDB=3l2y | SCENE= }} | ||
===The structure of C-reactive protein bound to phosphoethanolamine=== | ===The structure of C-reactive protein bound to phosphoethanolamine=== | ||
{{ABSTRACT_PUBMED_21360619}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CRP_HUMAN CRP_HUMAN]] Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:021360619</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Kolstoe, S E.]] | [[Category: Kolstoe, S E.]] | ||
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[[Category: Pepys, M B.]] | [[Category: Pepys, M B.]] | ||
[[Category: Wood, S P.]] | [[Category: Wood, S P.]] | ||
[[Category: Acute phase]] | |||
[[Category: Acute phase reactant]] | |||
[[Category: Calcium-binding protein]] | |||
[[Category: Immune system]] | |||
[[Category: Metal-binding]] | |||
[[Category: Pentraxin]] | |||
[[Category: Phosphoethanolamine]] | |||
[[Category: Pyrrolidone carboxylic acid]] | |||
[[Category: Secreted]] | |||
Revision as of 20:30, 4 April 2013
The structure of C-reactive protein bound to phosphoethanolamine
Template:ABSTRACT PUBMED 21360619
Function
[CRP_HUMAN] Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
About this Structure
3l2y is a 20 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Mikolajek H, Kolstoe SE, Pye VE, Mangione P, Pepys MB, Wood SP. Structural basis of ligand specificity in the human pentraxins, C-reactive protein and serum amyloid P component. J Mol Recognit. 2011 Mar;24(2):371-7. doi: 10.1002/jmr.1090. PMID:21360619 doi:10.1002/jmr.1090
