Sandbox Reserved 348: Difference between revisions
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{{Template:Sandbox_Reserved_BCMB307}} | {{Template:Sandbox_Reserved_BCMB307}} | ||
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{{ STRUCTURE_1ppb | PDB=1ppb | SCENE=Sandbox_Reserved_348/Cpk/1 }} | {{ STRUCTURE_1ppb | PDB=1ppb | SCENE=Sandbox_Reserved_348/Cpk/1 }} | ||
[[Image:1ppb.png|thumb|left|300px|This are a caption.<ref name="Placeholder">PMID:2583108</ref>]] | |||
Thrombin is a [[trypsin]]-like [[Serine Protease|serine protease]] which is best known for its role in blood clotting. In humans, the F2 gene codes for prothrombin, which is also known as Coagulation Factor II.<ref name="Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively.">PMID:3474786</ref><ref name="Nucleotide sequence of the gene for human prothrombin.">PMID:2825773</ref> Clevage of prothrombin to form activated α-thrombin is a key step in the final common pathway of blood clotting, because thrombin activates fibrin, which creates cross-linked fibrin clots.<ref name="Thrombin interactions.">12970119</ref> | |||
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=3D Structures of α-Thrombin= | =3D Structures of α-Thrombin= | ||
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*[[1uma]] | *[[1uma]] | ||
*[[1de7]] | *[[1de7]] | ||
=3D Structures of Prothrombin= | |||
*[[2afq]] | |||
=See Also= | =See Also= | ||
*[[Fibrin]] | *[[Fibrin]] | ||
*[[Trypsin]] | *[[Trypsin]] | ||
*[[Serine Protease]] | |||
=External Resources= | =External Resources= | ||
