Translocation domain: Difference between revisions
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New page: The Colicin translocation domain is found at the T terminus of the colicin protein. This structure is involved in the recruitment of a group of proteins, either from the Tol system... |
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[[Image: Colicin Translocation.png|500px|thumb| A diagram showing a generalised translocation path of the colicins from group A and group B into the cytoplasm, not showing all types of cytotoxic activity<ref> PMID: 21060316</ref>]] | [[Image: Colicin Translocation.png|500px|thumb| A diagram showing a generalised translocation path of the colicins from group A and group B into the cytoplasm, not showing all types of cytotoxic activity<ref> PMID: 21060316</ref>]] | ||
Colicins that recruit the proteins from the Tol system are classed as being group A colicins, and those using the Ton system are group B colicins. Group A colicins also recruit a co-receptor to aid their translocation, such as [[OmpF]] or [[Tol C]]<ref> PMID: 6281233 </ref>, which is not something also seen in Group B colicins<ref> PMID: 17347522 </ref>. They may indiscriminately recruit other membrane proteins to aid translocation, that have transient interaction - this would explain why they have not yet been identified. | |||
Once they have bound to the receptor and recruited translocation proteins, many colicins are known to unfold before moving across the membrane into the cytoplasm. However, the diameter of the unfolded peptide exceeds the diameter of the pores formed by the proteins recruited into the area<ref> PMID: 1537329 </ref><ref> PMID: 1380671 </ref>. | |||
==References== | ==References== | ||
<references/> | <references/> | ||
