Sandbox Reserved 162: Difference between revisions

Human Interleukin-6 (IL-6) is a immune protein categorized under hematopoietins much like Interleukin-11, Leukemia Inhibitory Factor (LIF), Oncostatin M (OM), Ciliary Neurotrophic Factor (CNTF), and Cardiotrophin-1 (CT-1) <ref>Sehgal P. et al, "Interleukin-6-type cytokines."  Annals of the New York Academy of Sciences, 1995, 762</ref>. IL-6 is produced by various types of lymphoid and non-lymphoid cells, such as T cells, B cells, monocytes, fibroblasts, kerationcytes, endothelial cells, mesangium cells, and several tumor cells <ref>Kishimoto, T. "The Biology of Interleukin 6." Am J Hematol, Jul, 1989, 74(1), 1-10.</ref>. Since its discovery, it has been known by many names including: interferon-ß2 (IFN-ß2)<ref>Weissenbach I. et al, "Two interferon mRNAs in human fibroblasts: In vitro translation and Escherichia coli cloning studies."  Proc Narl Acad Sci USA, 777152-7156.</ref><ref>Zilberstein et al, "Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines."  EMBO J 5:2529-2537.</ref>, 26-kD protein<ref>Content, J. et al, "Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta."  Pmc Natl Acad Sci USA, 792768-2772.</ref>, , B-cell stimulatory factor-2 (BSF-2), hepatocyte stimulating factor (HSF), cytotoxic T-cell differentiation factor (CDF), interleukin-HP1 (IL-HP1), monocyte-granulocyte inducer type 2 (MGI-2), and hybridoma/plasmacytoma growth factor (HPGF/HGF). It wasn't until December of 1988 that is was givin the final moniker of IL-6 (PDB: 1IL6).