Sandbox Reserved 196: Difference between revisions
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== Introduction == | == Introduction == | ||
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Ribonuclease B is structurally the same as RNase A. However is has an additional catalytic activity caused by the attachment of polysaccharrides at the Asn-34. This small change allows RNase B to hydrolyze double-stranded RNA at ionic strengths where RNase A has no activity. This shows that small changes in the active sites of very similar molecules can lead to todally new roles and activities. | Ribonuclease B is structurally the same as RNase A. However is has an additional catalytic activity caused by the attachment of polysaccharrides at the Asn-34. This small change allows RNase B to hydrolyze double-stranded RNA at ionic strengths where RNase A has no activity. This shows that small changes in the active sites of very similar molecules can lead to todally new roles and activities. | ||
== Background == | == Background == | ||
[[Image:RNaseB.png | thumb|left|RNase B]] | [[Image:RNaseB.png | thumb|left|RNase B]] | ||
3D pic (Right) | |||
have at least 2 green links | |||
<Structure load='1rbb' size='300' frame='true' align='right' caption=' | <Structure load='1rbb' size='300' frame='true' align='right' caption='3D picture of RNase B dimer' scene='Sandbox_Reserved_196/Rbb_basic/1' /> | ||
<Structure load='1rbj' size='300' frame='true' align='right' caption='Ribonuclease B with a strand of DNA in active site' scene='Sandbox_Reserved_196/Secondary_structure/4' /> | |||
== Biology of RNase B == | == Biology of RNase B == | ||
green links | |||
== Description == | == Description == | ||
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== References == | == References == | ||
<ref group=>PMID:3680242</ref><references /> | <ref group=>PMID:3680242</ref><references /> | ||
