Sandbox Reserved 168: Difference between revisions
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== Function == | == Function == | ||
SKI, as mentioned before is an oncoprotein that represses TGF-beta and nuclear receptor signaling from telling the cell to slow down and stop dividing. It is also involved in the regulation of cellular transformation and differentiation. The SKI protein has been associated with tumors at large levels of cellular concentrations and it has been shown to interfere with normal cellular functioning. It was recently discovered that SKI plays a role not only inside the nucleus but also outside of the nucleus in the cytoplasm. Scientists have previously shown that Ski disrupts normal cell functioning by directly disrupting the expression of genes inside the cell’s nucleus<ref name="function"> Walsh K, Rowe M.Fall 2002. Scientists Identify the role of Important Cancer Protein. Brookhaven National Laboratory. http://www.bnl.gov/bnlweb/pubaf/pr/2002/bnlpr103102.htm </ref> | SKI, as mentioned before is an oncoprotein that represses TGF-beta and nuclear receptor signaling from telling the cell to slow down and stop dividing. It is also involved in the regulation of cellular transformation and differentiation<ref name="function"> Medrano E. 2003. Repression of TGF-B signaling by the oncogenic protein SKI in human melanomas: Consequences for proliferation, survival, and metastasis. http://www.nature.com/onc/journal/v22/n20/full/1206452a.html</ref>. The SKI protein has been associated with tumors at large levels of cellular concentrations and it has been shown to interfere with normal cellular functioning. It was recently discovered that SKI plays a role not only inside the nucleus but also outside of the nucleus in the cytoplasm. Scientists have previously shown that Ski disrupts normal cell functioning by directly disrupting the expression of genes inside the cell’s nucleus<ref name="function"> Walsh K, Rowe M.Fall 2002. Scientists Identify the role of Important Cancer Protein. Brookhaven National Laboratory. http://www.bnl.gov/bnlweb/pubaf/pr/2002/bnlpr103102.htm </ref> | ||
== Clinical Applications == | == Clinical Applications == | ||
