3nz7: Difference between revisions

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Revision as of 07:29, 30 March 2011

File:3nz7.png

Template:STRUCTURE 3nz7

A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine ligand containing bis-3-fluoropyrrolidine end side chains

Template:ABSTRACT PUBMED 21221451

About this Structure

3nz7 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. Campbell NH, Smith DL, Reszka AP, Neidle S, O'Hagan D. Fluorine in medicinal chemistry: beta-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA. Org Biomol Chem. 2011 Mar 7;9(5):1328-31. Epub 2011 Jan 10. PMID:21221451 doi:10.1039/c0ob00886a

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