Sandbox Reserved 321: Difference between revisions

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==Structure of inhA==

The overall strucuture of the inhA enzyme of ''[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]'' consists of a single domain with two substructures<ref name ="making drugs for inhA">PMID:5882878</ref>.

The overall strucuture of the inhA enzyme of ''[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]'' consists of a single domain with two substructures that are connected by short loop<ref name ="making drugs for inhA">PMID:5882878</ref>.

===Substructure 1 of inhA===

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Substructure one consists of 6 parallel β strands and 4 α helices interwoven together to form a core α/β structure that contains the n-terminal domain<ref name ="making drugs for inhA">PMID:5882878</ref>.

The first substructure can be further broken down into two sections, the <scene name='Sandbox_Reserved_321/Substructure1section1/7'>first section</scene> consisting of two β strands <scene name='Sandbox_Reserved_321/B-1_and_b-2/4'>(B-1 and B-2)</scene>and two short α helicies <scene name='Sandbox_Reserved_321/A-1_and_a-2/2'>(A-1 and A-2)</scene><ref name ="making drugs for inhA">PMID:5882878</ref>.

The first section is connected to the <scene name='Sandbox_Reserved_321/Section2substructure1/1'>second section</scene> by a β strand <scene name='Sandbox_Reserved_321/B-3/1'>(B-3)</scene> that crosses over the two domains, and leads into the second section initiating at the fourth α helix (A-4)</scene><ref name ="making drugs for inhA">PMID:5882878</ref>. A-4 then leads into a fifth strand β (B-5), followed by a 25 residue α helix (A-5), and ~~finally~~ the ~~last~~ strand β (B-6)<ref name ="making drugs for inhA">PMID:5882878</ref>.

The first section is connected to the <scene name='Sandbox_Reserved_321/Section2substructure1/1'>second section</scene> by a β strand <scene name='Sandbox_Reserved_321/B-3/1'>(B-3)</scene> that crosses over the two domains, and leads into the second section initiating at the third α helix <scene name='Sandbox_Reserved_321/A-3/1'>(A-3)</scene><ref name ="making drugs for inhA">PMID:5882878</ref>. (A-3) is connected by a long loop to a 14 residue β strand <scene name='Sandbox_Reserved_321/B-4/2'>(B-4)</scene>that then leads into the fourth α helix <scene name='Sandbox_Reserved_321/A-4/2'>(A-4)</scene><ref name ="making drugs for inhA">PMID:5882878</ref>. A-4 then leads into a fifth strand β <scene name='Sandbox_Reserved_321/B-5/1'>(B-5)</scene>, followed by a 25 residue α helix <scene name='Sandbox_Reserved_321/A-5/2'>(A-5)</scene>, and into the final strand β <scene name='Sandbox_Reserved_321/B-6/1'>(B-6)</scene><ref name ="making drugs for inhA">PMID:5882878</ref>.

===Substructure 2 of inhA===

Sandbox Reserved 321: Difference between revisions

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@@ Line 20: / Line 20: @@
 ==Structure of inhA==
-The overall strucuture of the inhA enzyme of ''[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]'' consists of a single domain with two substructures<ref name ="making drugs for inhA">PMID:5882878</ref>.
+The overall strucuture of the inhA enzyme of ''[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]'' consists of a single domain with two substructures that are connected by short loop<ref name ="making drugs for inhA">PMID:5882878</ref>.
 ===Substructure 1 of inhA===
@@ Line 26: / Line 26: @@
 Substructure one consists of 6 parallel β strands and 4 α helices interwoven together to form a core α/β structure that contains the n-terminal domain<ref name ="making drugs for inhA">PMID:5882878</ref>.
 The first substructure can be further broken down into two sections, the <scene name='Sandbox_Reserved_321/Substructure1section1/7'>first section</scene> consisting of two β strands <scene name='Sandbox_Reserved_321/B-1_and_b-2/4'>(B-1 and B-2)</scene>and two short α helicies <scene name='Sandbox_Reserved_321/A-1_and_a-2/2'>(A-1 and A-2)</scene><ref name ="making drugs for inhA">PMID:5882878</ref>.
-The first section is connected to the <scene name='Sandbox_Reserved_321/Section2substructure1/1'>second section</scene> by a β strand <scene name='Sandbox_Reserved_321/B-3/1'>(B-3)</scene> that crosses over the two domains, and leads into the second section initiating at the fourth α helix (A-4)</scene><ref name ="making drugs for inhA">PMID:5882878</ref>.  A-4 then leads into a fifth strand β (B-5), followed by a 25 residue α helix (A-5), and finally the last strand β (B-6)<ref name ="making drugs for inhA">PMID:5882878</ref>.
+The first section is connected to the <scene name='Sandbox_Reserved_321/Section2substructure1/1'>second section</scene> by a β strand <scene name='Sandbox_Reserved_321/B-3/1'>(B-3)</scene> that crosses over the two domains, and leads into the second section initiating at the third α helix <scene name='Sandbox_Reserved_321/A-3/1'>(A-3)</scene><ref name ="making drugs for inhA">PMID:5882878</ref>.  (A-3) is connected by a long loop to a 14 residue β strand <scene name='Sandbox_Reserved_321/B-4/2'>(B-4)</scene>that then leads into the fourth α helix <scene name='Sandbox_Reserved_321/A-4/2'>(A-4)</scene><ref name ="making drugs for inhA">PMID:5882878</ref>. A-4 then leads into a fifth strand β <scene name='Sandbox_Reserved_321/B-5/1'>(B-5)</scene>, followed by a 25 residue α helix <scene name='Sandbox_Reserved_321/A-5/2'>(A-5)</scene>, and into the final strand β <scene name='Sandbox_Reserved_321/B-6/1'>(B-6)</scene><ref name ="making drugs for inhA">PMID:5882878</ref>.
 ===Substructure 2 of inhA===