Sandbox Reserved 309: Difference between revisions
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Globular with a central core made by <scene name='Sandbox_Reserved_309/Beta_parallel_sheet/1'>beta parallel sheet</scene> surrounded by alpha helices, a P-loop motif at the N-terminus that binds ATP, and two regions (LID and NMP). <ref name=Bellinzoni>PMID: 16672241 </ref> | Globular with a central core made by <scene name='Sandbox_Reserved_309/Beta_parallel_sheet/1'>beta parallel sheet</scene> surrounded by alpha helices, a P-loop motif at the N-terminus that binds ATP, and two regions (LID and NMP). <ref name=Bellinzoni>PMID: 16672241 </ref> | ||
=Function= | =Function= | ||
Involved in nucleotide biosynthesis. | *Involved in nucleotide biosynthesis, which is very important as the intervention point for therapeutic agents. *Catalyzes the reversible Mg2+ dependent transfer of the terminal phosphate group from ATP to AMP releasing two molecules of ADP. | ||
*LID and NMP binding regions go through a significant conformational change during the catalysis reaction depicted below. <ref name=Bellinzoni>PMID: 16672241 </ref> | |||
=Catalytic Mechanism= | =Catalytic Mechanism= | ||
ADP+MgADP↔MgATP+AMP | ADP+MgADP↔MgATP+AMP | ||
