Prp24: Difference between revisions

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== Structure ==
== Structure ==


<Structure load='2ghp' size='300' frame='true' align='right' caption='X-ray crystallographic structure of the first three RRMs of Prp24, shown here as the octameric protein observed in the crystal structure' scene='Sandbox_Reserved_340/2ghp/3'/>
<Structure load='2ghp' size='300' frame='true' align='right' caption='' scene='Sandbox_Reserved_340/2ghp/3'/>


The key structural elements of Prp24 are the conserved RNA recognition motifs (RRMs).  These motifs are found in many proteins with RNA binding properties and contain conserved RNP elements that are recognizable by their primary sequence <ref name="Shannon"/>.  For several years, Prp24 was thought to contain three RRMs, termed RRM 1, RRM 2, and RRM 3 <ref name="Shannon"/>.  However, analysis of homologs of Prp24 from several different species allowed the identification of a fourth RRM in Prp24 of ''S. cerevisiae'', albeit one that was much less highly conserved and not easily recognizable by its RNP-consensus domain <ref name="Rader"/>.
The key structural elements of Prp24 are the conserved RNA recognition motifs (RRMs).  These motifs are found in many proteins with RNA binding properties and contain conserved RNP elements that are recognizable by their primary sequence <ref name="Shannon"/>.  For several years, Prp24 was thought to contain three RRMs, termed RRM 1, RRM 2, and RRM 3 <ref name="Shannon"/>.  However, analysis of homologs of Prp24 from several different species allowed the identification of a fourth RRM in Prp24 of ''S. cerevisiae'', albeit one that was much less highly conserved and not easily recognizable by its RNP-consensus domain <ref name="Rader"/>.