Sandbox Reserved 346: Difference between revisions
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In the human body it is produced by the brain, skeletal muscles, liver, pancreas, red blood cells, and kidneys. The wide range of tissues in which it is made, separates it from the similar enzyme alanine transaminase (ALT) which is found primarily in the liver. The level of AST in the body can be used as a marker for tissue disease or damage. As well, AST and ALT levels can be compared to pinpoint whether tissue damage is primarily found within the liver. | In the human body it is produced by the brain, skeletal muscles, liver, pancreas, red blood cells, and kidneys. The wide range of tissues in which it is made, separates it from the similar enzyme alanine transaminase (ALT) which is found primarily in the liver. The level of AST in the body can be used as a marker for tissue disease or damage. As well, AST and ALT levels can be compared to pinpoint whether tissue damage is primarily found within the liver. | ||
=='''Structure'''== | =='''Structure'''== | ||
<Structure load='1b4x' size='300' frame='true' align='left' caption='Ligand' scene='Sandbox_Reserved_346/ | <Structure load='1b4x' size='300' frame='true' align='left' caption='Ligand' scene='Sandbox_Reserved_346/Ast/1'/> | ||
<scene name='Sandbox_Reserved_346/Ast/1'>AST</scene> is a homodimer that contains 16 alpha helices and a Beta-sheet formed from 7 parallel and antiparallel strands.Each subunit contain an equivalent active site. The subunits connect between their large domains and between the the N-terminal residues and the large domain of the other subunit. This structure of AST varies minutely among organisms rangin from ''E. coli'' to humans. The structure of the active site is highly conserved, and their is a sequence homology of 25%. | <scene name='Sandbox_Reserved_346/Ast/1'>AST</scene> is a homodimer that contains 16 alpha helices and a Beta-sheet formed from 7 parallel and antiparallel strands.Each subunit contain an equivalent active site. The subunits connect between their large domains and between the the N-terminal residues and the large domain of the other subunit. This structure of AST varies minutely among organisms rangin from ''E. coli'' to humans. The structure of the active site is highly conserved, and their is a sequence homology of 25%. | ||
