Sandbox Reserved 200: Difference between revisions
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The RNase A 3D domain swapped oligomers show significant biological activity including allostery, antitumor, and immunorepression activity. In antitumor activity, the oligomers degrade dsRNA, but they are also capable of degrading DNA and RNA hybrids which can be found during the translation of genes.<ref name="tumor"/> This same activity has not been observed in the monomer and the non-3D domain swapped oligomers .<ref name="liu98">PMID: | The RNase A 3D domain swapped oligomers show significant biological activity including allostery, antitumor, and immunorepression activity. In antitumor activity, the oligomers degrade dsRNA, but they are also capable of degrading DNA and RNA hybrids which can be found during the translation of genes.<ref name="tumor"/> This same activity has not been observed in the monomer and the non-3D domain swapped oligomers .<ref name="liu98">PMID:9520384</ref > This could be due to the fact that the monomer has a cystolic RNase A inhibitor that is unable to inhibit the active sites of the oligomers. <ref name="liu01">PMID:11790847</ref > | ||
