Sandbox Reserved 200: Difference between revisions

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The <scene name='Sandbox_Reserved_200/Minor_trimer/1'>minor trimer</scene> forms a cyclic propeller like shape. It is 3D domain swapped at the C-terminus of the beta strand.<ref name="liu01"/> ~~The~~ minor trimer ~~has the same exact active sites as the~~ monomer. ~~As with~~ the dimer, the structure of the monomer is conserved except for at the <scene name='Sandbox_Reserved_200/Minor_trimer/2'>hinge loop</scene>.

The <scene name='Sandbox_Reserved_200/Minor_trimer/1'>minor trimer</scene> forms a cyclic propeller like shape. It is 3D domain swapped at the C-terminus of the beta strand.<ref name="liu01"/> No domain swapping a the N-terminus has been seen. When the minor trimer dissociates, it forms a dimer and a monomer. The minor and major dimer are both formed, but the major dimer is much more common.<ref name="liu01"/>

Similar to dimer, the structure of the monomer is conserved except for the <scene name='Sandbox_Reserved_200/Minor_trimer/2'>hinge loop</scene>. The <scene name='Sandbox_Reserved_200/Minor_trimer/3'>active sites</scene> of the trimers are made up of the same amino acid residues as the monomers and dimers.

==Medical Relevance==

Sandbox Reserved 200: Difference between revisions

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 <Structure load='1JS0' size='400' frame='true' align='left' caption='Minor Trimer of RNase A' scene='Sandbox_Reserved_200/Minor_trimer/1' />
-The <scene name='Sandbox_Reserved_200/Minor_trimer/1'>minor trimer</scene> forms a cyclic propeller like shape.  It is 3D domain swapped at the C-terminus of the beta strand.<ref name="liu01"/>  The minor trimer has the same exact active sites as the monomer.  As with the dimer, the structure of the monomer is conserved except for at the <scene name='Sandbox_Reserved_200/Minor_trimer/2'>hinge loop</scene>.
+The <scene name='Sandbox_Reserved_200/Minor_trimer/1'>minor trimer</scene> forms a cyclic propeller like shape.  It is 3D domain swapped at the C-terminus of the beta strand.<ref name="liu01"/>  No domain swapping a the N-terminus has been seen.  When the minor trimer dissociates, it forms a dimer and a monomer.  The minor and major dimer are both formed, but the major dimer is much more common.<ref name="liu01"/>
+Similar to dimer, the structure of the monomer is conserved except for the <scene name='Sandbox_Reserved_200/Minor_trimer/2'>hinge loop</scene>.  The <scene name='Sandbox_Reserved_200/Minor_trimer/3'>active sites</scene> of the trimers are made up of the same amino acid residues as the monomers and dimers.
 ==Medical Relevance==